Extracellular vesicles induced by innate immune pathways in cancer immunosurveillance (P14)

癌症免疫监视中先天免疫途径诱导的细胞外囊泡（P14）

• 批准号: 405444168
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin III
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/405444168?language=en
• 关键词: Extracellular; vesicles; induced; innate; immune

Secreted extracellular vesicles (EVs) are emerging as an important mechanism of intercellular communication in the tumour microenvironment. Aberrant immune signalling pathways in tumour cells that regulate the biogenesis and often immunosuppressive function of such EVs remain unknown. Led by our recent discoveries about cancer-intrinsic roles of IFN-I-coupled pathways in modulation of cancer immunosurveillance, we here aim to understand the role of tumour-intrinsic cytosolic RIG-I and STING in the generation and function of immunogenic EVs to influence cancer immunosurveillance and -therapy.

分泌性细胞外囊泡（EVs）是肿瘤微环境中细胞间通讯的重要机制。肿瘤细胞中的异常免疫信号通路调节此类ev的生物发生和免疫抑制功能仍不清楚。基于我们最近关于ifn -i偶联通路在调节癌症免疫监视中的内在作用的发现，我们在此旨在了解肿瘤内在细胞质RIG-I和STING在免疫原性EVs的产生和功能中的作用，从而影响癌症免疫监视和治疗。