Functional mapping of Ras induced immune signalling components in intestinal cancer (P13)

Ras 诱导的肠癌免疫信号成分的功能图谱 (P13)

• 批准号: 405443995
• 金额: --
• 依托单位: Institut für Molekulare Onkologie und Funktionelle Genomik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/405443995?language=en
• 关键词: Functional; mapping; Ras; induced; immune

RAS family members are the most common human proto-oncogenes. Analysing intestinal cancer evolution, we found that Kras-mutated alleles are very frequently being amplified at the adenoma to carcinoma transition. We uncovered that this oncogenic dosage amplification induces strong immune signalling programs in intestinal epithelia, including defined chemokine, cytokine and growth factor responses. Here, we propose to (i) study the molecular mechanisms by which mutant KRAS activates distinct immune signalling components and (ii) to characterize the precise nature and biological effects of such Ras-dosage dependent immune signalling programs in oncogenesis.

RAS家族成员是人类最常见的原癌基因。分析肠癌演变，我们发现Kras突变等位基因在腺瘤到癌的过渡中非常频繁地被扩增。我们发现，这种致癌剂量放大在肠上皮细胞中诱导强烈的免疫信号传导程序，包括确定的趋化因子、细胞因子和生长因子反应。在这里，我们建议（i）研究突变KRAS激活不同的免疫信号传导组分的分子机制，（ii）表征这种Ras剂量依赖性免疫信号传导程序在肿瘤发生中的精确性质和生物学效应。