Control morphology and drug release of nanodrugs through templated crystallization of poorly water-soluble compounds

通过难溶性化合物的模板化结晶控制纳米药物的形态和药物释放

• 批准号: 22K14742
• 负责人: DAO THINGOCANH
• 金额: $ 2.66万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K14742/
• 关键词: nanodrugs; metallic cluster; reprecipitation; crystallization; cancer therapy; noble metal; prodrug; templated crystallize; nanomedicine

The purpose of this research is to design and fabricate a carrier-free nanodrug via templated-crystallization method using SN-38, the active metabolite of irinotecan, acts as a potent inhibitor of DNA topoisomerase I. In this work, several derivatives of SN-38 were selected as the anticancer moiety, and Au cluster of ca. 10 nm was selected as a template. The nanodrugs are fabricated by reprecipitation method. The modified Au/SN38-Chol nanoparticles were successfully fabricated in several sizes by adjusting the reprecipitation conditions. The existence of Au in the nanodrugs was confirmed in the UV-Vis spectra with visible absorbance at ca. 550 nm. The formation yield of the hybrid nanodrugs were suggested to be affected by the hydrophilicity of Au surface.

本研究的目的是利用伊立替康的活性代谢物SN-38作为DNA拓扑异构酶I的有效抑制剂，通过模板结晶法设计并制备无载体纳米药物。本工作选择了SN-38的几种衍生物作为抗癌活性基团，并以约100 μ g/ml的Au簇为靶点。10 nm作为模板。采用再沉淀法制备纳米药物。通过调节再沉淀条件，成功地制备了不同尺寸的改性Au/SN 38-Chol纳米粒子。紫外-可见吸收光谱表明纳米药物中存在Au。550 nm。杂化纳米药物的形成率受到Au表面亲水性的影响。

项目成果

Influence of Ag:Pt Composition of Au@Ag@Pt Core@Multi-Shell Nanoparticles Prepared by Co-Reduction Method

Ag:Pt组成对共还原法制备Au@Ag@Pt核@多壳纳米粒子的影响

• 发表时间: 2022
• 作者: H.-J. Lee;Anh T. N. Dao;H. Kasai;K. Kaneko
• 通讯作者: K. Kaneko

Introduction of Nanomedicine Delivery Based on Hybrid Materials

基于混合材料的纳米药物输送介绍

• 发表时间: 2023
• 作者: 佐藤知哉;中村 聡;浦田千尋;穂積 篤;Anh T. N. Dao
• 通讯作者: Anh T. N. Dao

Creation of Hybrid Nanomedicine Composed of Au and SN-38 Prodrugs towards Chemo-Photothermal Therapy

创建由 Au 和 SN-38 前药组成的混合纳米药物用于化学光热疗法

• 发表时间: 2022
• 作者: T. Liu;Anh T. N. Dao;H. Kasai;R. Suzuki;Y. Koseki
• 通讯作者: Y. Koseki

Nanomedicine: Do we need other materials beside drug?

纳米医学：除了药物还需要其他材料吗？

• 发表时间: 2022
• 作者: T. Liu;Anh T. N. Dao;H. Kasai;R. Suzuki;Y. Koseki;Anh T. N. Dao
• 通讯作者: Anh T. N. Dao

Influence of the silver or platinum feeding ratio on the synthesis of Au@Ag-Pt core@multi-shell nanoparticles

银铂投料比对Au@Ag-Pt核@多壳纳米颗粒合成的影响

• 发表时间: 2022
• 作者: H.-J Lee;D. Hanyu;Anh T. N. Dao;H. Kasai;K. Kaneko
• 通讯作者: K. Kaneko