Control morphology and drug release of nanodrugs through templated crystallization of poorly water-soluble compounds

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The purpose of this research is to design and fabricate a carrier-free nanodrug via templated-crystallization method using SN-38, the active metabolite of irinotecan, acts as a potent inhibitor of DNA topoisomerase I. In this work, several derivatives of SN-38 were selected as the anticancer moiety, and Au cluster of ca. 10 nm was selected as a template. The nanodrugs are fabricated by reprecipitation method. The modified Au/SN38-Chol nanoparticles were successfully fabricated in several sizes by adjusting the reprecipitation conditions. The existence of Au in the nanodrugs was confirmed in the UV-Vis spectra with visible absorbance at ca. 550 nm. The formation yield of the hybrid nanodrugs were suggested to be affected by the hydrophilicity of Au surface.