Identification of factors influencing zoonotic transmission of MERS-Coronavirus in Kenya

确定影响肯尼亚 MERS 冠状病毒人畜共患传播的因素

• 批准号: 405556422
• 负责人: Professor Dr. Marcel Müller
• 金额: --
• 依托单位: Institut für Virologie (CCM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/405556422?language=en
• 关键词: Identification; factors; influencing; zoonotic; transmission

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) emerged in Saudi Arabia in 2012 and is associated with an atypical life-threatening form of pneumonia in humans.MERS-CoV causes severe human morbidity and mortality and is the focus of epidemic and pandemic concern. Dromedaries are the likely source for human MERS infections. Although MERS-CoV has a broad temporal and geographical distribution in African dromedaries, zoonotic transmission from dromedaries to humans seems to be limited in Kenya.Much remains unknown regarding the pathogen and its transmission, and more resources should be devoted to increasing local knowledge and expertise in the geographic regions of its incidence. Our project will expand diagnostic and laboratory infrastructures in Kenya, train multidisciplinary international experts, identify outbreak hotspots, and develop urgently needed in silico and in vitro risk assessment tools. This combination of complementary aims will greatly facilitate the fight against MERS-CoV in particular, and will serve as a model for the fight against other emerging pathogens worldwide.

中东呼吸综合征冠状病毒（MERS-CoV）于2012年在沙特阿拉伯出现，并与一种非典型的危及生命的人类肺炎形式相关。MERS-CoV导致严重的人类发病率和死亡率，是流行病和大流行病关注的焦点。单峰骆驼是人类MERS感染的可能来源。虽然中东呼吸综合征冠状病毒在非洲单峰骆驼中有广泛的时间和地理分布，但在肯尼亚，从单峰骆驼到人类的人畜共患病传播似乎是有限的。关于病原体及其传播，仍有许多未知数，应投入更多资源，以增加其发病地理区域的当地知识和专业知识。我们的项目将扩大肯尼亚的诊断和实验室基础设施，培训多学科国际专家，确定疫情热点，并开发急需的计算机和体外风险评估工具。这种互补目标的结合将大大促进特别是MERS CoV的斗争，并将成为全球打击其他新兴病原体的模式。