Direct DNA and RNA synthesis: From nucleosides over nucleotides to oligomers (P12)

在该项目中，起点是DNA核苷合成，其中核碱基本身在与乙醛的有机催化样反应中被激活，从而允许通过与甘油醛反应靶向组装脱氧核糖核苷。我们现在的目标是将这种合成途径扩展到RNA核苷的合成。此外，我们计划使用prebiotically合理的有机催化剂将核苷磷酸化为RNA和DNA核苷酸。在进一步的步骤中，制备的RNA和DNA核苷酸将在寡聚反应中被激活，使得我们可以构建随机的DNA和RNA寡聚序列。

In this project, the starting point is the DNA nucleoside synthesis where the nucleobase itself is activated in an organo-catalytic-like reaction with acetaldehyde, thus allowing a targeted assembly of the deoxyribonucleosides by reaction with glyceraldehyde. We now aim to extend this synthesis route to the synthesis of RNA nucleosides. Furthermore, we plan to phosphorylate the nucleosides to RNA and DNA nucleotides using a prebiotically plausible organocatalyst. In a further step, the prepared RNA and DNA nucleotides will be activated in an oligomerization reaction so that we can build random DNA and RNA oligomeric sequences.