Elucidating roles of Wnt gradients and PCP signaling in establishing neural polarity during column formation

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Wnt/PCP signaling is evolutionarily conserved from Drosophila to humans and is highly related to cancer and Alzheimer’s disease. Nevertheless, recent studies argue contradictory results about the roles of Wnt ligands in regulating PCP signaling. Our study utilizes an excellent model system to clarify this problem by revealing evolutionarily conserved mechanisms of column formation.In this project, we have generated knock-in alleles to visualized subcellular distribution of PCP proteins; 2) we identified the subcellular distribution of PCP proteins in the singal core columnar neurons by combining specific neurons-FLPase strains that express FLPase specifically in core columnar neurons with the knock-in strains. These findings and results provide an important basis for our research.