Exploiting the heterogeneity of CD4 T cells to create more effective Tregs

到目前为止，该项目已经确定，在体外观察到的iTregs的不同功能不是由于产生抗炎分子，而是Tregs本身在生存能力上的细胞内在差异。这背后的确切原因尚不清楚，但似乎可以归结为不同人群对il - 2的敏感性差异。在体内系统中，在不同的过敏性炎症情况下（气道炎症和食源性炎症），不同的Tregs促进了不同类型的免疫反应（通过在肺和小肠中观察到的特定细胞免疫浸润来判断）。两组treg都没有得到确切的所谓“更好”的保护，但却截然不同。

The project has, thus far, determined that the differential functioning of iTregs observed in vitro is not due to the production of anti-inflammatory molecules, but rather a cell-intrinsic difference in the survivability of the Tregs themselves. The exact reasons behind this are still being determined, but it appears to come down to differences in the sensitivity of the different groups for IL2.Moving to in vivo systems, in different contexts of allergic inflammation (both airway and food-based), the different Tregs have promoted different types of immune responses (as judged by the particular cellular immune infiltrate observed in both the lungs and small intestine). Neither group of Tregs has elicited what could definitively be called "better" protection, but rather different.