Exploiting the heterogeneity of CD4 T cells to create more effective Tregs

到目前为止，该项目已经确定，在体外观察到的iTregs的不同功能不是由于抗炎分子的产生，而是细胞本身在Tregs生存能力方面的内在差异。这背后的确切原因仍在确定中，但似乎归结为不同组对IL2的敏感性的差异。转移到体内系统，在不同的过敏性炎症环境中(包括呼吸道和基于食物的)，不同的Treg促进了不同类型的免疫反应(根据在肺和小肠中观察到的特殊细胞免疫渗透来判断)。这两组特雷格人都没有得到可以被明确称为“更好”的保护，但却截然不同。

The project has, thus far, determined that the differential functioning of iTregs observed in vitro is not due to the production of anti-inflammatory molecules, but rather a cell-intrinsic difference in the survivability of the Tregs themselves. The exact reasons behind this are still being determined, but it appears to come down to differences in the sensitivity of the different groups for IL2.Moving to in vivo systems, in different contexts of allergic inflammation (both airway and food-based), the different Tregs have promoted different types of immune responses (as judged by the particular cellular immune infiltrate observed in both the lungs and small intestine). Neither group of Tregs has elicited what could definitively be called "better" protection, but rather different.