Translation termination in human mitochondria: Why do we need four release factors? (A14*)

人类线粒体的翻译终止：为什么我们需要四种释放因子？

• 批准号: 405771880
• 金额: --
• 依托单位: Institut für Molekularbiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/405771880?language=en
• 关键词: Translation; termination; human; mitochondria; Why

In human mitochondria there are four predicted class I release factors (RFs): mtRF1a, mtRF1, ICT1 and C12ORF65. However, a codon-dependent translation termination activity has been only demonstrated for mtRF1a so far. It has been suggested that mtRF1a is sufficient to terminate all mitochondrial transcripts. The role of the other RFs in mitochondrial translation termination remains elusive. Here, we will investigate the function of mtRF1, which shows significant differences in the decoding motifs compared to other RFs.

在人类线粒体中，有四种预测的I类释放因子（RF）：mtRF1a，mtRF1，ICT1和C12ORF65。然而，密码子依赖的翻译终止活性迄今为止仅被证明为mtRF1a。有人认为mtRF1a足以终止所有线粒体转录本。其他RF在线粒体翻译终止中的作用仍然难以捉摸。在这里，我们将研究mtRF1的功能，与其他RF相比，mtRF1在解码基序方面表现出显着差异。