Role of IL-33 in Squamous cell carcinoma metastasis and proliferation

鳞状细胞癌（SCC）是人类常见的恶性肿瘤之一，由于其较高的转移潜力，与其他角化细胞癌相比，SCC患者的死亡率也很高。它主要是由长时间暴露于紫外线辐射（UVR）引起的DNA突变发展而来，主要发生在鳞状细胞中，它可以通过血管和淋巴结转移，并引起严重的并发症。我们的研究目的是阐明IL-33诱导是否有利于SCC的发展和转移，并找出其可能的机制。我们对IL-33 -/-小鼠和WT小鼠进行了SCC肿瘤进展的实验研究。将小鼠分为2组；1) il-33 -/- dmba / tpa, 2) wt dmba / tpa。到目前为止，研究结果表明，IL-33 -/-小鼠的肿瘤进展较小。

Squamous cell carcinoma (SCC) is one of the common forms of human malignancies and because of its relatively high metastasis potential, compared to other keratinocyte cancer, the mortality rate of SCC patients is also high. Primarily it develops from DNA mutations caused by prolonged exposure to ultraviolet radiation (UVR) mainly in the squamous cells and it can metastasize through blood vessels and lymph nodes, and cause serious complications. The purpose of our research is to elucidate whether IL-33 induction can be beneficial against SCC development and metastasis and find out the possible mechanism for that. We have conducted experiments to investigate SCC tumor progression IL-33 -/- mice and WT mice. Mice were divided into 2 groups; 1) IL-33 -/- DMBA/TPA, 2) WT DMBA/TPA. Until now, Results have shown that the IL-33 -/- mice showed less tumor progression.