Role of IL-33 in Squamous cell carcinoma metastasis and proliferation

IL-33在鳞状细胞癌转移和增殖中的作用

• 批准号: 22K16269
• 负责人: アンサリ トゥーバ・マサラット
• 金额: $ 2.91万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K16269/
• 关键词: IL-33; Squamous cell carcinoma; PD-1; ADAR-1; PD-1 resistance

Squamous cell carcinoma (SCC) is one of the common forms of human malignancies and because of its relatively high metastasis potential, compared to other keratinocyte cancer, the mortality rate of SCC patients is also high. Primarily it develops from DNA mutations caused by prolonged exposure to ultraviolet radiation (UVR) mainly in the squamous cells and it can metastasize through blood vessels and lymph nodes, and cause serious complications. The purpose of our research is to elucidate whether IL-33 induction can be beneficial against SCC development and metastasis and find out the possible mechanism for that. We have conducted experiments to investigate SCC tumor progression IL-33 -/- mice and WT mice. Mice were divided into 2 groups; 1) IL-33 -/- DMBA/TPA, 2) WT DMBA/TPA. Until now, Results have shown that the IL-33 -/- mice showed less tumor progression.

鳞状细胞癌(SCC)是人类常见的恶性肿瘤之一，由于其较高的转移潜能，与其他角质形成细胞癌相比，其死亡率也较高。它主要是由于长期暴露于紫外线辐射(UVR)引起的DNA突变而发展起来的，主要发生在鳞状细胞中，可通过血管和淋巴结转移，并导致严重的并发症。本研究的目的是阐明IL-33的诱导是否有助于抗鳞状细胞癌的发生和转移，并探讨其可能的机制。我们已经进行了实验来研究鳞癌肿瘤的进展，IL-33-/-小鼠和WT小鼠。将小鼠分为2组：1)IL-33-/-DMBA/TPA组，2)WT DMBA/TPA组。到目前为止，结果表明IL-33-/-小鼠的肿瘤进展较小。