Functional role of meprin β in Alzheimer’s disease (A15*)

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The project analyzes the involvement of meprin β in the amyloidogenic pathway. Meprin β generates N-terminally truncated Aβ peptides in vitro. The physiologic function of meprin β in neurons, astrocytes and microglia cells with regard to Aβ peptide generation in vivo will be addressed. Using cell-specific meprin β-overexpressing mice, it will be analyzed how the proteolytic processing of APP is orchestrated by meprin β and BACE1 and the competitive α-secretase ADAM10, and whether meprin β is involved in the onset and progression of Alzheimer's disease.