Platelets as modulators of neuro-inflammation in the ischaemic brain (B06)

血小板作为缺血性大脑神经炎症的调节剂 (B06)

• 批准号: 406478588
• 金额: --
• 依托单位: Neurologische Klinik und Poliklinik
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406478588?language=en
• 关键词: Platelets; modulators; neuro; inflammation; ischaemic

Here, advanced imaging techniques together with transgenic mouse models and pharmacological tools are key to gain mechanistic insight into platelet-immune cell relevant complications. We found that platelet secretion is an important mediator of detrimental cellular interactions at the vascular interface during ischaemia/reperfusion (I/R) injury. Next, we study the role of platelets for penumbral tissue loss during large vascular occlusion, and the key molecular and cellular interactions in comparison with those in the early phase after reperfusion as well as during cerebral venous (sinus) thrombosis.

在这里，先进的成像技术、转基因小鼠模型和药理学工具是获得血小板免疫细胞相关并发症机制的关键。我们发现血小板分泌是缺血/再灌注（I/R）损伤时血管界面有害细胞相互作用的重要介质。接下来，我们将研究血小板在大血管闭塞时半影组织损失中的作用，以及与再灌注后早期以及脑静脉（窦）血栓形成时的关键分子和细胞相互作用。