Platelets as modulators of neuro-inflammation in the ischaemic brain (B06)

在这里，先进的成像技术以及转基因小鼠模型和药理学工具是从机制上深入了解与血小板免疫细胞相关的并发症的关键。我们发现，在缺血/再灌注(I/R)损伤过程中，血小板分泌是血管界面有害细胞相互作用的重要介质。接下来，我们研究了血小板在大血管闭塞期间半暗带组织丢失中的作用，以及与再灌注早期和脑静脉(窦)血栓形成过程中的关键分子和细胞相互作用。

Here, advanced imaging techniques together with transgenic mouse models and pharmacological tools are key to gain mechanistic insight into platelet-immune cell relevant complications. We found that platelet secretion is an important mediator of detrimental cellular interactions at the vascular interface during ischaemia/reperfusion (I/R) injury. Next, we study the role of platelets for penumbral tissue loss during large vascular occlusion, and the key molecular and cellular interactions in comparison with those in the early phase after reperfusion as well as during cerebral venous (sinus) thrombosis.