Fine-mapping the contribution of sleep alterations to neurodegeneration – a prospective polysomnographic study in the general population

精细描绘睡眠改变对神经退行性变的影响——一项针对普通人群的前瞻性多导睡眠图研究

• 批准号: 406711066
• 负责人: Professor Dr. Hans Jörgen Grabe
• 金额: --
• 依托单位: Klinik und Poliklinik für Psychiatrie und Psychotherapie (Greifswald)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/406711066?language=en
• 关键词: Fine; mapping; contribution; sleep; alterations

Dementias are neurodegenerative disorders caused by a complex interaction between modifiable and non-modifiable factors. Among these, sleep has been recently gaining attention, with a study estimating that up to 15% of Alzheimer cases could be delayed or prevented through the effective treatment of sleep disorders. In the initial project, we found strong associations between obstructive sleep apnoea and advanced brain ageing and white matter hyperintensity burden, as well as between slow-wave sleep and Alzheimer-related brain atrophy patterns. But while these results are compatible with hypothesized pathophysiological pathways, some controversy remains regarding other published results. This might indicate that the categorization and/or temporal compression of the used metrics of sleep macro-architecture and obstructive sleep apnoea might not accurately reflect the relevant sleep processes. Using cross-sectional and longitudinal polysomnography and structural MRI data from the Study of Health in Pomerania (SHIP-Trend-0/1) general population study, we therefore propose to extend our analyses to EEG-based microstructural events, global sleep markers incorporating temporal and individual-specific dynamics of sleep and hypoxic markers assessing the temporal and structural composition of these events. We believe that these markers will clarify some of the controversy and provide additional insight into the impact of sleep and obstructive sleep apnoea on dementia-related neurodegeneration.

痴呆症是由可改变因素和不可改变因素之间复杂的相互作用引起的神经退行性疾病。其中，睡眠最近引起了人们的关注，一项研究估计，通过有效治疗睡眠障碍，可以推迟或预防高达 15% 的阿尔茨海默病病例。在最初的项目中，我们发现阻塞性睡眠呼吸暂停与晚期大脑老化和白质高信号负担之间以及慢波睡眠与阿尔茨海默病相关的脑萎缩模式之间存在密切关联。但是，尽管这些结果与假设的病理生理学途径相一致，但关于其他已发表的结果仍然存在一些争议。这可能表明所使用的睡眠宏观结构和阻塞性睡眠呼吸暂停指标的分类和/或时间压缩可能无法准确反映相关的睡眠过程。因此，利用来自波美拉尼亚健康研究 (SHIP-Trend-0/1) 一般人群研究的横断面和纵向多导睡眠图以及结构 MRI 数据，我们建议将我们的分析扩展到基于脑电图的微结构事件、纳入时间和个体特异性睡眠动态的全局睡眠标记以及评估这些事件的时间和结构组成的缺氧标记。我们相信这些标记物将澄清一些争议，并为睡眠和阻塞性睡眠呼吸暂停对痴呆相关神经变性的影响提供更多见解。