The Cooperative Asymmetric Copper Catalysis and Visible-Light Photocatalysis for Sustainable Enantioselective Synthesis

考虑到手性分子在药物、候选药物和天然产物中的首要重要性，高度期望更稳健的合成方法。在这种背景下，我提出了一个更实用的方法来合成有价值的手性化合物利用协同催化。特别是，发展的双重和强大的催化体系的C-H键功能化的简单酮，以及更刚性的酰胺在一个对映选择性的方式是令人惊讶的未知。因此，引入无添加剂、协同的“不对称铜催化”和“可见光催化”将是一个理想且更实用的选择，这不仅可以在不对称合成中开启新的范例，而且还可以克服来自先前方法的许多主要障碍。因此，除了引入新的合成途径外，该战略还将为传统方法提供环境友好和减少废物的替代方法。

Having considered the prime importance of chiral molecules in pharmaceuticals, drug candidates, and natural products, the more robust synthetic methods are highly desired. In that context, I propose a more practical approach for the synthesis of valuable chiral compounds utilizing cooperative catalysis.In particular, the development of dual and powerful catalytic systems for C−H bond functionalization of simple Ketones as well as for more rigid amides in an enantioselective fashion is surprisingly unknown. Therefore, the introduction of additive free, cooperative “asymmetric copper catalysis” and “visible-light photocatalysis” would be an ideal and more practical option, which may not only unlock new paradigms in asymmetric synthesis but also overcome the number of major barriers from the previous methods. This strategy would, therefore, provide the environmentally friendly and waste-reducing alternatives to the classical methodologies, in addition to the introduction of new synthetic pathways.