Social aspects of restrictive eating behavior in anorexia nervosa

神经性厌食症限制性饮食行为的社会方面

• 批准号: 407671229
• 负责人: Dr. Lena Rademacher
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/407671229?language=en
• 关键词: Social; aspects; restrictive; eating; behavior

The aim of the planned project is to increase the understanding how social aspects might be involved in food-restrictive behavior in anorexia nervosa (AN). To this end, AN patients (restrictive type) and healthy participants will perform two experimental paradigms during functional magnetic resonance imaging. In the first paradigm, neural responses to anticipated food and non-food rewards will be examined and personal rewards (experience of own win) will be contrasted to vicarious rewards (experience of others’ wins). I hypothesize that reactions in the reward system of healthy subjects will be stronger in response to personal rewards compared to those for another person and will depend on the subjective value attributed to the reward (rated after fMRI scanning). However, in patients with AN I expect to find different responses: I assume that neural responses and value ratings of AN patients will not differ from healthy controls regarding food-unrelated (monetary) rewards, but will be reduced during the anticipation of personal food rewards due to negative appraisal which is based on the reluctance to gain weight and goals such as food avoidance. Furthermore, I expect structures of the cognitive control network to be more active in AN patients in response to food-related stimuli. However, when food rewards are vicariously processed I assume that reward responses will not be diminished in AN patients, since these are not associated with (personal) weight gain or in conflict with own cognitive goals. Instead, they might be increased compared to healthy participants, indicating social comparison processes in AN and vicarious pleasure from others' eating. I the second paradigm, neural activations related to social eating situations will be investigated, contrasting situations in which participants imagine eating to situations in which only other persons are eating. I assume that imagination of eating in the presence of others elicits shame in AN patients due to social comparison processes, because it reveals a lack of self-control and deviation from personal goals and ideals. Thus, I hypothesize that patients with AN will express stronger feelings of shame (in post-scan ratings) for social situations which involve the imagination of personal eating and will show stronger activation of shame-associated brain networks compared to healthy controls. In contrast, when they imagine being in social situations where they only observe someone else eating, patients with AN might even react with pride and vicarious pleasure (associated with increased activations in the mesolimbic reward system).With the planned project, I expect to provide important information about mechanisms that underlie restrictive eating behavior in AN what might help to develop more effective treatment strategies to reduce relapse or prevent the onset of the disorder in individuals at risk.

计划项目的目的是增加对社会方面如何参与神经性厌食症（AN）食物限制行为的理解。为此，在功能磁共振成像过程中，AN患者（限制性型）和健康参与者将进行两种实验范式。在第一种范式中，对预期食物和非食物奖励的神经反应将被检查，个人奖励（自己获胜的经验）将与替代奖励（他人获胜的经验）进行对比。我假设，健康受试者的奖励系统对个人奖励的反应会比对他人奖励的反应更强烈，这将取决于奖励的主观价值（在fMRI扫描后评定）。然而，在AN患者中，我预计会发现不同的反应：我假设AN患者的神经反应和价值评级在与食物无关的（金钱）奖励方面与健康对照组没有区别，但在预期个人食物奖励时，由于基于不愿增加体重和目标（如食物回避）的负面评价，会减少。此外，我希望AN患者的认知控制网络结构在对食物相关刺激的反应中更加活跃。然而，当食物奖励被间接处理时，我认为奖励反应不会在AN患者中减少，因为这些与（个人）体重增加无关，也与自己的认知目标相冲突。相反，与健康参与者相比，它们可能会增加，这表明AN的社会比较过程和他人饮食的替代快感。在第二个范式中，将研究与社交进食情境相关的神经激活，对比参与者想象进食的情境和只有其他人在进食的情境。我认为，想象在别人面前吃东西会引起AN患者的羞耻感，这是由于社会比较过程，因为它显示了自我控制的缺乏和对个人目标和理想的偏离。因此，我假设AN患者在涉及个人饮食想象的社交情境中会表现出更强烈的羞耻感（在扫描后评分中），并且与健康对照组相比，会表现出更强的与羞耻相关的大脑网络激活。相比之下，当他们想象自己处于只观察别人吃饭的社交场合时，AN患者甚至可能会表现出骄傲和替代快感（与中脑边缘奖励系统的激活增加有关）。通过计划中的项目，我希望提供有关AN限制性饮食行为背后机制的重要信息，这可能有助于开发更有效的治疗策略，以减少复发或预防高危个体的疾病发作。