Biomimetic lipidic self-assembly materials for protein encapsulation

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This project intends to improve understanding of the interactions between proteins and lipidic materials to guide the development of new biomaterials. Proteins and peptides play an increasingly important role as drugs, vaccines and diagnostics. However, these fragile, often large, macromolecules come with challenges for drug delivery. Lipid-based materials are ideal matrices for encapsulation of functionally active proteins. They also offer advantages as drug delivery vehicles including controlled release properties. The combination of strategies creates an ideal delivery system for protein therapeutics. The project aims to characterise the physicochemical interactions between the protein and the lipid matrix. This may guide the development of novel lipidic materials for the encapsulation and controlled release of protein therapeutics.