Biomimetic lipidic self-assembly materials for protein encapsulation

用于蛋白质封装的仿生脂质自组装材料

• 批准号: DE160101281
• 负责人: Prof Charlotte Conn
• 金额: $ 21.01万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-04-01 至 2019-10-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE160101281
• 关键词: Biomimetic; lipidic; self; assembly; materials

This project intends to improve understanding of the interactions between proteins and lipidic materials to guide the development of new biomaterials. Proteins and peptides play an increasingly important role as drugs, vaccines and diagnostics. However, these fragile, often large, macromolecules come with challenges for drug delivery. Lipid-based materials are ideal matrices for encapsulation of functionally active proteins. They also offer advantages as drug delivery vehicles including controlled release properties. The combination of strategies creates an ideal delivery system for protein therapeutics. The project aims to characterise the physicochemical interactions between the protein and the lipid matrix. This may guide the development of novel lipidic materials for the encapsulation and controlled release of protein therapeutics.

该项目旨在提高对蛋白质和生物材料之间相互作用的理解，以指导新生物材料的开发。蛋白质和肽作为药物、疫苗和诊断剂发挥着越来越重要的作用。然而，这些脆弱的、通常较大的大分子给药物递送带来了挑战。基于脂质的材料是用于包封功能活性蛋白质的理想基质。它们还提供作为药物递送载体的优点，包括控释性质。这些策略的结合为蛋白质治疗创造了理想的递送系统。该项目旨在研究蛋白质和脂质基质之间的物理化学相互作用。这可能会指导新的包封材料的开发和蛋白质治疗药物的控制释放。