Effects of impaired glucocorticoid receptor function in hemorrhagic shock-induced lung injury with pre-existing cigarette smoke-induced chronic obstructive pulmonary disease (B07*)

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When mice receive intensive care treatment, we found that a lack of GR dimerization (GRdim) increases mortality, aggravates hypotension, and further impairs lung function after challenge with lipopolysaccharides. Therefore, B07 N hypothesizes that lung injury and systemic inflammation after hemorrhagic shock are exacerbated in GRdim mice, which is further promoted by pre-traumatic cigarette smoke exposure-induced COPD. We expect that glucocorticoid (GC) treatment improves lung function and reduces inflammation through synergistic gene induction, which is promoted by inflammatory- and anti-inflammatory-acting signaling pathways dependent on GRdim in alternative macrophages.