Slowing polycystic kidney disease by inhibition of HIF-1α-dependent- and calcium-mediated secretory signaling pathways (A02)

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Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by continuous cyst growth due to fluid secretion into the cyst lumen. Our preliminary work indicates that ATP-dependent, Ca2+-activated Cl- secretion as well as HIF-1α and ROS signaling contribute to this fluid transport. Here, we will test if cyst progression can be slowed down by pharmacological inhibition of these pathways. In addition, we will analyze the mechanism leading to luminal ATP release and its effect on cyst enlargement. The expected results will help to understand the underlying mechanisms of continuous cyst expansion in ADPKD and to identify applicable drug targets to inhibit cyst growth and preserve renal function.