Gut microbiome in renoprotection (A01)

良好的微生物群对肾脏保护作用 (A01)

• 批准号: 418106480
• 金额: --
• 依托单位: Max-Delbrück-Centrum für Molekulare Medizin (MDC) in der Helmholtz-Gemeinschaft
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418106480?language=en
• 关键词: Gut; microbiome; renoprotection; A01

This project investigates key mechanisms of gut microbiome involvement in hypertensive CKD for identifying new targets in renoprotection. A deeper understanding of microbiota-host interaction in hypertensive CKD is needed, especially with regards to inflammation. Proof-of-concept experiments will be performed in a trans-species approach using microbiome sequencing, metabolomics and immunophenotyping alongside quantification of renal damage, allowing for an integrative network analysis. The effects of commonly used drugs known to interfere with the microbiota as well as the effects of microbiota from CKD patients will be investigated in established rodent models.

该项目研究了肠道微生物组参与高血压CKD的关键机制，以确定肾保护的新靶点。需要更深入地了解高血压CKD中的微生物-宿主相互作用，特别是关于炎症。概念验证实验将采用跨物种方法进行，使用微生物组测序，代谢组学和免疫表型分析以及肾损伤的定量，从而进行综合网络分析。将在已建立的啮齿动物模型中研究已知干扰微生物群的常用药物的作用以及CKD患者微生物群的作用。