Gut microbiome in renoprotection (A01)

本项目研究肠道微生物群参与高血压慢性肾脏病的关键机制，以确定肾脏保护的新靶点。需要对高血压CKD中的微生物群-宿主相互作用有更深入的了解，特别是关于炎症。概念验证实验将以跨物种的方法进行，使用微生物组测序、代谢组学和免疫表型分析，同时量化肾脏损害，从而进行综合网络分析。将在已建立的啮齿动物模型中研究已知干扰微生物区系的常用药物的影响以及CKD患者的微生物区系的影响。

This project investigates key mechanisms of gut microbiome involvement in hypertensive CKD for identifying new targets in renoprotection. A deeper understanding of microbiota-host interaction in hypertensive CKD is needed, especially with regards to inflammation. Proof-of-concept experiments will be performed in a trans-species approach using microbiome sequencing, metabolomics and immunophenotyping alongside quantification of renal damage, allowing for an integrative network analysis. The effects of commonly used drugs known to interfere with the microbiota as well as the effects of microbiota from CKD patients will be investigated in established rodent models.