Impact of exclusive enteral nutrition on microbiome signatures and function in pediatric Crohn’s disease (P01)

纯肠内营养对儿科克罗恩病微生物组特征和功能的影响 (P01)

• 批准号: 418380081
• 金额: --
• 依托单位: Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/418380081?language=en
• 关键词: Impact; exclusive; enteral; nutrition; microbiome

Crohn’s disease (CD) is one of the two main entities of idiopathic inflammatory bowel disease (IBD). In the second funding phase, the tandem will specify the diet-induced changes in the intestinal microbiome for therapeutic efficacy of exclusive enteral nutrition (EEN) in pediatric Crohn’s disease. EEN-associated signatures will be characterized using the combined approach of continuous culture, gnotobiotic mice and pig models. In this context, the role of dietary fiber in provoking disease relapse will be evaluated. Longitudinal bacterial- and metabolite-profiling of treatment responsive and refractory patients will be implemented to identify functionally relevant microbiome targets in response to EEN, leading to the development of protective synthetic bacterial consortia. The perspective of this project is to develop a microbiome-based maintenance therapy for pediatric CD patients.

克罗恩病（CD）是特发性炎症性肠病（IBD）的两个主要实体之一。在第二个资助阶段，串联将详细说明饮食引起的肠道微生物组变化，以确定小儿克罗恩病的独家肠内营养（EEN）的治疗效果。将使用连续培养、无菌小鼠和猪模型的组合方法表征EEN相关特征。在这种情况下，将评估膳食纤维在引起疾病复发中的作用。将对治疗反应和难治性患者进行纵向细菌和代谢物分析，以确定EEN反应中功能相关的微生物组靶标，从而开发保护性合成细菌聚生体。该项目的目的是为儿童CD患者开发一种基于微生物组的维持治疗。