Managing calcineurin inhibitor-induced nephrotoxicity for renoprotection (C04)

点击翻译按钮获取中文摘要

Calcineurin inhibitors such as cyclosporin A and tacrolimus are first-line immunosuppressive drugs widely used to prevent rejection of transplanted organs. Despite their success, nephrotoxic side effects such as damage of the glomeruli, vasculature, and tubulointerstitium are common. Here, drugs may affect proteostasis by causing cell stress and maladaption of the pathways of protein quality control. A disequilibrium between cytoprotective and proapoptotic responses may result. This project aims at understanding the functions of cellular proteostasis under calcineurin inhibition, and at discovering renoprotective strategies such as the application of small molecular chaperones.