Targeting collecting duct barrier function for renoprotection (C06)

肾集管由紧密的上皮组成，在肾髓质间质和尿腔之间保持陡峭的浓度梯度，同时促进高度调节的水和离子的运输机制。在本项目中，我们将分析急性肾损伤期间和之后收集管损伤的生理、细胞和分子机制及其后果，以及其在限制慢性肾脏疾病进展中的作用。我们将利用急性肾损伤的细胞和小鼠模型，并结合遗传和药理学方法来调节集管上皮屏障功能。

The renal collecting duct is composed of a tight epithelium that maintains steep concentration gradients between the renal medullary interstitium and the urinary space and, at the same time, facilitates highly regulated transport mechanisms for water and ions. In this project, we will analyze the physiological, cellular and molecular mechanisms and consequences of collecting duct injury during and after acute kidney injury, and its role in limiting the progression to chronic kidney disease. We will utilize cellular and murine models of acute kidney injury and combine them with genetic and pharmacologic approaches to modulate collecting duct epithelial barrier function.