Targeting collecting duct barrier function for renoprotection (C06)

肾集合管由紧密的上皮组成，其在肾髓质髓质和泌尿空间之间保持陡峭的浓度梯度，并且同时促进水和离子的高度调节的运输机制。在本项目中，我们将分析急性肾损伤期间和之后集合管损伤的生理，细胞和分子机制和后果，以及其在限制慢性肾脏疾病进展中的作用。我们将利用急性肾损伤的细胞和小鼠模型，并将其与遗传和药理学方法结合联合收割机来调节集合管上皮屏障功能。

The renal collecting duct is composed of a tight epithelium that maintains steep concentration gradients between the renal medullary interstitium and the urinary space and, at the same time, facilitates highly regulated transport mechanisms for water and ions. In this project, we will analyze the physiological, cellular and molecular mechanisms and consequences of collecting duct injury during and after acute kidney injury, and its role in limiting the progression to chronic kidney disease. We will utilize cellular and murine models of acute kidney injury and combine them with genetic and pharmacologic approaches to modulate collecting duct epithelial barrier function.