Structural determinants of avian magnetoreception (Sig03)

鸟类磁感受的结构决定因素 (Sig03)

• 批准号: 418844917
• 金额: --
• 依托单位: Institut für Biochemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418844917?language=en
• 关键词: Structural; determinants; avian; magnetoreception; Sig03

To achieve a comprehensive understanding of magnetoreception and vertebrate navigation, it is important to characterize the primary sensory proteins in which the biophysical detection of magnetic fields takes place, and to understand how the primary sensing event is translated into structural changes initiating the downstream signalling cascade. In project Sig03 we will elucidate the conformational spectrum of cryptochrome using molecular cryo-electron microscopy and single-particle reconstruction. Analysis of the conformational states of an avian cryptochrome at defined magnetic fields, will allow us to uncover the molecular mechanisms at the heart of this magnetic sensing process.

为了全面了解磁感受和脊椎动物导航，重要的是表征发生磁场生物物理检测的主要感觉蛋白，并了解主要传感事件如何转化为启动下游信号级联的结构变化。在 Sig03 项目中，我们将使用分子冷冻电子显微镜和单粒子重建来阐明隐花色素的构象谱。对鸟类隐花色素在特定磁场下的构象状态进行分析，将使我们能够揭示这种磁传感过程核心的分子机制。