Contested legitimacy of regenerative vs. established biomedicine in Brazil: On the circulation and co-regulation of immunostimulant therapies for autoimmunity
巴西再生生物医学与现有生物医学的合法性争议:关于自身免疫免疫刺激疗法的循环和共同调节
基本信息
- 批准号:419940268
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2019
- 资助国家:德国
- 起止时间:2018-12-31 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
How does the development of a new therapeutic model, whose potential emergence threatens the hegemony of an already established biomedical model, affect, and how is it affected by law, science and society? To anchor this question in a particular context, I conduct an anthropological study into how scientific innovation, established biomedicine and informal health care co-exist and interface in contemporary Brazil, and how their relations are mediated by legal institutions and other actors. For it, I delineate and explore ‘life assemblages’ related and interconnected through the use of ‘immunostimulant drugs’ for the treatment of autoimmune diseases, which are conventionally treated with ‘immunosuppressant drugs’ worldwide.My central case study is the ‘anti-brucellic vaccine’ (vacina anti-brucélica or VAB) – a drug produced in Brazil and largely used by patients against several autoimmune diseases. After more than 10 years seeking to become authorized by medico-legal authorities, the VAB remained an object of controversies and was recently taken as basis for the development of a further biotechnological innovation called Complex of Essential Amino Acids (CAE) that is currently commercialized as a ‘manipulated drug’ while rnew andomized controlled trials are being prepared. Inspired by Actor-Network-Theory, I follow the VAB/CAE in order to re-trace associations and map the main relations that have constituted it as a biotechnological innovative agent and, simultaneously, as an object of judicial dispute and regulation. Related to that I compare the VAB/CAE case to other cases of circulation and regulation of immunostimulant drugs as contested innovations in Brazil, such as the synthetic phosphoethanolamine. By doing this, I weave an ethnography of the VAB/CAE out of a multi-sited ethnographic fieldwork through participant observation (including autoethnography) and, complementarily, digital methods and documentary research.I argue that, from an international perspective, the VAB/CAE case reveals how research into the production, circulation and regulation of immunostimulant therapies for autoimmune diseases in Brazil can provide critical insights into the emergence of regenerative medicine as a transnational process. Moreover, whilst shedding light on legal conflicts between established regulatory science and challenging innovative biotechnologies, the VAB/CAE case highlights how the renewal of established biomedicine for autoimmunity partially unfolds by means of informal pharmaceutical economies, other cultures of legality and respective moralities.
一种新的治疗模式的发展,其潜在的出现威胁到已经建立的生物医学模式的霸权,是如何影响的,以及它如何受到法律、科学和社会的影响?为了将这个问题固定在特定的背景下,我进行了一项人类学研究,探讨科学创新、现有的生物医学和非正式医疗保健在当代巴西是如何共存和相互作用的,以及它们的关系是如何由法律机构和其他行为者调解的。为此,我勾勒和探索了相关和相互关联的“生命组合”,通过使用“免疫刺激药物”来治疗自身免疫性疾病,这些疾病在世界各地都是用“免疫抑制药”治疗的。我的中心案例研究是“抗布鲁氏菌疫苗”(Vacina anti-Brucélica,简称VAB),这是一种巴西生产的药物,主要用于治疗几种自身免疫性疾病。在寻求获得法医当局授权的10多年后,VAB仍然是一个有争议的对象,最近被视为开发一种名为必需氨基酸复合体(CAE)的进一步生物技术创新的基础,该药物目前作为一种“操纵药物”进行商业化,同时正在准备新的随机对照试验。受行动者-网络-理论的启发,我遵循VAB/CAE,以便重新追踪协会,并绘制构成它作为生物技术创新主体的主要关系,同时作为司法争议和监管的对象。与此相关的是,我将VAB/CAE案件与巴西作为有争议的创新的免疫刺激药物的流通和监管的其他案件进行了比较,例如合成磷乙醇胺。通过这样做,我通过参与者观察(包括自我人种学)以及补充的数字方法和文献研究,从多地点的民族志田野工作中编织出VAB/CAE的民族志。我认为,从国际角度来看,VAB/CAE案例揭示了对巴西自身免疫性疾病免疫刺激疗法的生产、流通和监管的研究如何为再生医学作为一个跨国过程的出现提供关键的见解。此外,VAB/CAE案虽然揭示了现有的管理科学和具有挑战性的创新生物技术之间的法律冲突,但也突显了更新现有的用于自身免疫的生物医学是如何通过非正式的制药经济、其他合法文化和各自的道德而部分展开的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dr. Márcio da Cunha Vilar, Ph.D.其他文献
Dr. Márcio da Cunha Vilar, Ph.D.的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Legitimacy and effective policing responses to domestic and family violence
对家庭暴力的合法性和有效的警务反应
- 批准号:
DP240102371 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Discovery Projects
DEVAL - Democratic Values and Authoritarian Legitimacy
DEVAL - 民主价值观和威权合法性
- 批准号:
EP/Y036832/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
Dynamism of the exercise of state jurisdiction as a means of sanction - legality, legitimacy and effectiveness
行使国家管辖权作为制裁手段的活力——合法性、合法性和有效性
- 批准号:
23K01113 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Balancing electoral manipulation and maintaining legitimacy: The Lao People's Revolutionary Party's mechanism for resolving electoral dilemmas.
平衡选举操纵与维护合法性:老挝人民革命党解决选举困境的机制
- 批准号:
23K01269 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Exploratory Study on Institutional Voids and Social Entrepreneur's Legitimacy in Emerging Economies
新兴经济体制度真空与社会企业家合法性探索性研究
- 批准号:
23K01563 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Diaspora Social Media Use and State Legitimacy in Nigeria
尼日利亚侨民社交媒体的使用和国家合法性
- 批准号:
2887175 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Studentship
Manipulation of Information in Crisis Response and the Legitimacy of China's Authoritarian Regime
危机应对中的信息操纵与中国威权政权的合法性
- 批准号:
23K12415 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Early-Career Scientists
Hyperphosphorylated tau and the molecular mechanisms of tauopathy
过度磷酸化的 tau 蛋白和 tau 蛋白病的分子机制
- 批准号:
10447253 - 财政年份:2022
- 资助金额:
-- - 项目类别:
UNM FIRST: Promoting Inclusive Excellence in Neuroscience and Data Science
UNM FIRST:促进神经科学和数据科学领域的包容性卓越
- 批准号:
10493710 - 财政年份:2022
- 资助金额:
-- - 项目类别:
The Problem of Legitimacy in Expert Advising and its Exacerbation Through Neoliberalism: A Case Study from the Research on Climate Mitigation
专家咨询的合法性问题及其因新自由主义而加剧:气候减缓研究的案例研究
- 批准号:
2752080 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Studentship