Project EpistemologyProduction of Knowledge between Contingency and Disposition using the example of CollaborativeResearch

项目认识论使用协作研究的例子在偶然性和处置之间产生知识

• 批准号: 423225684
• 负责人: Thomas Krämer
• 金额: --
• 依托单位国家: 德国
• 项目类别: Publication Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/423225684?language=en
• 关键词: Project; EpistemologyProduction; Knowledge; between; Contingency

The study draws up a methodological synopsis of concepts from Science Studies and New Materialism, in order to conceptualize collaborative research as an own field of research using the example of three cardiovascular Collaborative Research Centres (CRC) in Düsseldorf between 1968 and 2012 - among others with authors like Bachelard/Heidegger, Canguilhem, Latour, Rheinberger, Keating/Cambrosio. Along the lines of tension between institutional and methodological platforms (dispositions) and unpredictable results during the conduction of the CRCs (contingencies), the first chapter establishes a "project epistemology" which assumes that science does not discover but produces mutable drafts. With Bachelard, scientific projects are understood as dynamic intermediate spaces between the researching subject and the knowledge object to be produced in the research process, together with its instrumental-pictorial representations. With Latour translation chains are conveyed from the matter of the organism to the form of inscriptions in the life sciences. Epistemic things and technical objects in experimental systems (Rheinberger) are identified with CRCspecific experimental contingencies and institutional dispositions. The presentation of institutional history and clinical research at the Düsseldorf site is based on the platform concept of Keating/Cambrosio. In the second chapter, the local dispositions of the scientific and medical history of the hospital are clarified, which allowed to set up the first cardiovascular CRC 30 (1968-1985) in Düsseldorf. The analysis of the archive documents of the CRC 30 shows the historical-contingent initiation phase of the CRC funding program, the resonances between the optimization of the DFG Rules of Procedure and the development of cooperation structures as well as the research program of the CRC 30. Based on the presentation of the methodological spectrum of experimental cardiology, the second chapter concludes with the characterization of "translational gaps" - i.e. physiological incomparabilities between animal models and the clinical situation in humans. As a result, cardiovascular collaborative research focuses on the oscillation between holistic pathophysiological perspectives of clinicians and the reductive molecular biology perspectives of natural scientists: a CRC must translate these perspectives into a common problem horizon and bring them into synopsis for further research applications. DFG-Vordojck 54.011 - 03/18 Seite 4 von 8 Whether the laboratory mouse has the potential to close these translational gaps and act as a bridge between laboratory and clinic is answered in the third chapter. The study focuses on the transgenic mouse models used in CRC 612 (2002-2012). As hybrids between epistemic things and technical objects, the mice display their own possibilities due to their experimental materiality and resistance and change the understanding of normal and pathological of the CRC researchers.

这项研究概述了科学研究和新唯物主义的概念，以杜塞尔多夫的三个心血管合作研究中心(CRC)为例，将合作研究概念化为一个自己的研究领域--其中包括与巴舍拉德/海德格尔、坎吉勒姆、拉图尔、莱因伯格、基廷/坎布罗西奥等人的合作。按照机构和方法平台(处置)和CRC实施期间不可预测的结果(意外情况)之间的紧张关系，第一章建立了一种“项目认识论”，假定科学不发现而是产生可变的草案。在巴什拉看来，科学项目被理解为研究主体和研究过程中产生的知识客体之间的动态中介空间，以及它的工具-图画表征。在拉图尔的翻译中，链条从有机体的内容传达到生命科学中的铭文形式。实验系统(Rheinberger)中的认知事物和技术对象被识别为特定于CRC的实验偶然性和制度配置。杜塞尔多夫医院的机构历史和临床研究的介绍是基于基廷/坎布罗西奥的平台概念。在第二章中，阐明了医院科学史和医学史的地方配置，从而允许在杜塞尔多夫建立第一个心血管CRC30(1968-1985)。对《儿童权利公约》30号档案文件的分析表明，《儿童权利公约》筹资方案处于历史--临时启动阶段，《儿童权利公约》议事规则的优化与合作结构的发展以及《儿童权利公约》30的研究方案之间存在共鸣。在介绍实验心脏病学方法学的基础上，第二章总结了“翻译鸿沟”的特征--即动物模型与人类临床情况之间的生理上的不可比性。因此，心血管合作研究的重点是临床医生的整体病理生理学观点和自然科学家的还原分子生物学观点之间的振荡：CRC必须将这些观点转化为共同的问题视界，并将其纳入提纲，以便进一步研究应用。DFG-Vordojck 54.011-03/18 Site 4 von 8实验室小鼠是否有潜力弥合这些翻译差距，并充当实验室和临床之间的桥梁，这在第三章中得到了回答。这项研究的重点是CRC 612(2002-2012)中使用的转基因小鼠模型。小鼠作为认知物和技术客体的杂交体，由于其实验的物质性和抵抗力，展现了自己的可能性，改变了CRC研究人员对正常和病理的理解。