Project EpistemologyProduction of Knowledge between Contingency and Disposition using the example of CollaborativeResearch

该研究对科学研究和新唯物主义的概念进行了方法论概述，以1968年至2012年期间位于<s:1>塞尔多夫的三个心血管合作研究中心（CRC）为例，将合作研究概念化为一个独立的研究领域，其中包括巴舍拉德/海德格尔、坎圭莱姆、拉图尔、莱茵伯格、基廷/坎布罗西奥等作者。沿着制度和方法论平台（倾向）之间的紧张关系，以及在CRCs（偶然性）的实施过程中不可预测的结果，第一章建立了一个“项目认识论”，它假设科学不会发现而是产生可变的草稿。在巴舍拉看来，科学项目被理解为研究主体和研究过程中产生的知识客体之间的动态中间空间，以及它的工具性图像表示。通过拉图尔，翻译链从生物体的物质传递到生命科学中的铭文形式。实验系统中的认知事物和技术对象（莱茵伯格）与crc特定的实验偶然性和制度倾向相一致。机构历史和临床研究在d<s:1> sseldorf站点的展示是基于Keating/Cambrosio的平台概念。在第二章中，阐明了医院的科学和医学史的地方配置，从而允许在<s:1>塞尔多夫建立第一个心血管CRC 30（1968-1985）。通过对CRC 30档案文件的分析，可以看出CRC资助计划启动阶段的历史偶然性、DFG议事规则的优化与合作结构的发展以及CRC 30研究计划之间的共鸣。在介绍实验心脏病学方法学谱的基础上，第二章总结了“翻译差距”的特征-即动物模型与人类临床情况之间的生理不可比性。因此，心血管合作研究的重点是临床医生的整体病理生理学观点和自然科学家的还原分子生物学观点之间的振荡：CRC必须将这些观点转化为共同的问题视野，并将其纳入进一步研究应用的概要。实验小鼠是否有潜力填补这些翻译空白，并作为实验室和临床之间的桥梁，将在第三章中回答。本研究的重点是CRC 612（2002-2012）中使用的转基因小鼠模型。小鼠作为认识性事物与技术性对象的混合体，由于其实验的物质性和抵抗性而展现出自身的可能性，改变了CRC研究者对正常与病理的认识。

The study draws up a methodological synopsis of concepts from Science Studies and New Materialism, in order to conceptualize collaborative research as an own field of research using the example of three cardiovascular Collaborative Research Centres (CRC) in Düsseldorf between 1968 and 2012 - among others with authors like Bachelard/Heidegger, Canguilhem, Latour, Rheinberger, Keating/Cambrosio. Along the lines of tension between institutional and methodological platforms (dispositions) and unpredictable results during the conduction of the CRCs (contingencies), the first chapter establishes a "project epistemology" which assumes that science does not discover but produces mutable drafts. With Bachelard, scientific projects are understood as dynamic intermediate spaces between the researching subject and the knowledge object to be produced in the research process, together with its instrumental-pictorial representations. With Latour translation chains are conveyed from the matter of the organism to the form of inscriptions in the life sciences. Epistemic things and technical objects in experimental systems (Rheinberger) are identified with CRCspecific experimental contingencies and institutional dispositions. The presentation of institutional history and clinical research at the Düsseldorf site is based on the platform concept of Keating/Cambrosio. In the second chapter, the local dispositions of the scientific and medical history of the hospital are clarified, which allowed to set up the first cardiovascular CRC 30 (1968-1985) in Düsseldorf. The analysis of the archive documents of the CRC 30 shows the historical-contingent initiation phase of the CRC funding program, the resonances between the optimization of the DFG Rules of Procedure and the development of cooperation structures as well as the research program of the CRC 30. Based on the presentation of the methodological spectrum of experimental cardiology, the second chapter concludes with the characterization of "translational gaps" - i.e. physiological incomparabilities between animal models and the clinical situation in humans. As a result, cardiovascular collaborative research focuses on the oscillation between holistic pathophysiological perspectives of clinicians and the reductive molecular biology perspectives of natural scientists: a CRC must translate these perspectives into a common problem horizon and bring them into synopsis for further research applications. DFG-Vordojck 54.011 - 03/18 Seite 4 von 8 Whether the laboratory mouse has the potential to close these translational gaps and act as a bridge between laboratory and clinic is answered in the third chapter. The study focuses on the transgenic mouse models used in CRC 612 (2002-2012). As hybrids between epistemic things and technical objects, the mice display their own possibilities due to their experimental materiality and resistance and change the understanding of normal and pathological of the CRC researchers.