VRE Network Baden-Württemberg

万古霉素耐药肠球菌（VRE）是引起医院感染的病原菌之一，因其多重耐药而成为感染控制的重点。因此，VRE定植或感染的患者通常需要在基本措施之外采取广泛的感染控制措施，这导致经济和临床负担。然而，这些控制措施的证据很少，需要进行持续的讨论。特别是在巴登-符腾堡州，已经发现整个德国的发病率增幅最高。目前还缺乏对医疗网络中VRE的迫切需要的时空分析。在包括四所大学医院以及区域保健提供者和社区医院在内的巴登- <s:1>符腾堡州VRE网络两步联合项目的过程中，我们打算进行这种分析，为个别保健中心和国家行政部门的知情决策创造证据。需要对感染控制干预措施进行评估和严格评估，需要分析风险因素，以了解德国南部乃至整个德国的VRE流行情况。在项目的第一阶段，将建立一个科学网络。巴登-符腾堡州VRE网络的目标是：(1)评估和分析区域医疗网络（包括所有与VRE相关的大学医院）的流行病学指标和患者转移数据；(2)系统的文献综述评估VRE作为感染因子的相关性，包括致病性、传播性、定菌的重要性和持续时间以及VRE感染的危险因素；(3)巴登-符腾堡州感染控制措施的标准化和网络伙伴之间的密切合作。该网络将为促进成员之间的科学交流、制定感染控制最佳做法建议和转移模式奠定基础，以进一步加强阻止VRE流行的政策。此外，该网络旨在编制科学研究方案，利用全基因组分析分析VRE传播。

Vancomycin-resistant Enterococci (VRE) are one of pathogens causing nosocomial infections which are in the focus of infection control due to their multidrug-resistance. Patients colonized or infected with VRE are therefore usually subject to extensive infection control measures beyond basic measures, which results in financial and clinical burden. The evidence for these control measures is, however, low and subject to ongoing discussions. Especially in the state of Baden-Württemberg the highest increase in incidence rates of whole Germany has been detected. Urgently needed spatial-temporal analyses of VRE in the healthcare networks are missing. In the course of the two-step joint project VRE network Baden-Württemberg, which includes the four university hospitals as well as regional healthcare providers and community hopsitals, we intend to undertake such analyses to create evidence for informed decision making for both individual healthcare centers and state administration. Infection control interventions need to be evaluated and critically appraised and risk factors need to be analysed to understand the VRE epidemic in Southern Germany and hopefully in all of Germany.During the first phase of the project a scientific network will be created. The goals of the VRE network Baden-Württemberg are: (1) assess and analyze epidemiological indicators and patient transferal data in the regional healthcare networks including all universities hospitals related to VRE, (2) systematic literature review assessing the relevance of VRE as infectious agent including pathogenicity, transmissibility, importance and duration of colonization and risk factors for VRE infection, (3) standardization of infection control measures within Baden-Württemberg and closer collaboration between network partners. The network will lay down the foundation to foster scientific exchange between members, the development of best-practice-recommendations for infection control and transferal patterns to further strengthen the policy to stop the VRE epidemic. Furthermore, the network aims to prepare scientific research proposals to analyze the VRE transmission with whole-genome analysis.