Tolerogenic function of dendritic cells in the gut-liver axis (B03)

肠-肝轴树突状细胞的耐受性功能（B03）

• 批准号: 424723108
• 金额: --
• 依托单位: Institut für Molekulare Medizin
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/424723108?language=en
• 关键词: Tolerogenic; function; dendritic; cells; gut

The intestine and liver act as a unit to maintain immune tolerance in the steady-state by inducing a population of regulatory T cells (Tregs). Intestinal dendritic cells (DCs) play a key role in Treg induction, however little is known about the tolerogenic potential of hepatic DCs. In this project, we will characterise the role of hepatic and intestinal lymph DCs in the induction of tolerogenic responses in the liver and gut as well as the functional and migratory properties of Foxp3+ Tregs induced by hepatic and intestinal DCs. Moreover, we will examine how the tolerogenic function of hepatic and intestinal DCs is altered in conditions of disrupted intestinal homeostasis.

肠道和肝脏作为一个单位，通过诱导调节性T细胞（Tcells）的群体来维持稳态的免疫耐受。肠树突状细胞（DC）在Treg诱导中起关键作用，然而对肝DC的致耐受性潜力知之甚少。在本项目中，我们将研究肝和肠淋巴DCs在诱导肝和肠耐受性反应中的作用，以及肝和肠DCs诱导的Foxp3+ TcR的功能和迁移特性。此外，我们将研究如何在肠道稳态破坏的条件下改变肝和肠DCs的致耐受性功能。