Tolerogenic function of dendritic cells in the gut-liver axis (B03)

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The intestine and liver act as a unit to maintain immune tolerance in the steady-state by inducing a population of regulatory T cells (Tregs). Intestinal dendritic cells (DCs) play a key role in Treg induction, however little is known about the tolerogenic potential of hepatic DCs. In this project, we will characterise the role of hepatic and intestinal lymph DCs in the induction of tolerogenic responses in the liver and gut as well as the functional and migratory properties of Foxp3+ Tregs induced by hepatic and intestinal DCs. Moreover, we will examine how the tolerogenic function of hepatic and intestinal DCs is altered in conditions of disrupted intestinal homeostasis.