Consequences of formyl-peptide receptor activation to the skin (A08)

甲酰肽受体激活对皮肤的影响 (A08)

• 批准号: 425996997
• 金额: --
• 依托单位: Lehrstuhl für Infektionsbiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/425996997?language=en
• 关键词: Consequences; formyl; peptide; receptor; activation

Leukocytes sense formylated peptides via formyl-peptide receptors (FPRs). Staphylococcal skin commensals and pathogens secrete phenol-soluble modulin (PSM) peptides, strong agonists of FPR2. FPR2 is important for the recruitment of leukocytes in early infections with S. aureus in mice. Although FPR2 is expressed also on human keratinocytes and skin fibroblasts, nearly nothing is known about the consequence of FPR activation in these cells. Our aim is to elucidate the role of FPRs and FPR-activating ligands in the inflammatory responses and in signal transduction in primary keratinocytes and skin fibroblasts. We will use cell culture and mouse models of skin wound healing, infection and systemic sclerosis to assess the potential of FPRs as targets for the prevention or therapy of skin diseases.

白细胞通过甲酰肽受体（FPRs）感知甲酰化肽。葡萄球菌皮肤分泌物和病原体分泌酚可溶性调节蛋白（PSM）肽，FPR2的强激动剂。FPR 2在S.小鼠中的金黄色葡萄球菌。尽管FPR2也在人角质形成细胞和皮肤成纤维细胞上表达，但对FPR在这些细胞中活化的结果几乎一无所知。我们的目的是阐明FPR和FPR激活配体在炎症反应和信号转导中的作用，在原代角质形成细胞和皮肤成纤维细胞。我们将使用细胞培养和皮肤伤口愈合、感染和系统性硬化症的小鼠模型来评估FPRs作为预防或治疗皮肤疾病的靶点的潜力。