Importance of hyaluronan-rich extracellular matrix for haematopoiesis, inflammation and structural remodelling in aortic aneurysms (B08)

富含透明质酸的细胞外基质对主动脉瘤造血、炎症和结构重塑的重要性 (B08)

• 批准号: 426129079
• 金额: --
• 依托单位: Institut für Molekulare Kardiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/426129079?language=en
• 关键词: Importance; hyaluronan; rich; extracellular; matrix

Genetic deletion of hyaluronan synthase 3 (HAS3) improves survival in a model of Angiotensin II-induced abdominal aortic aneurysms and dissections (AAA/AAD) due to reduced vessel ruptures in Apoe-/-/Has3-/- mice. Besides, no thoracic aortic aneurysms (TAA) were detected in the absence of HAS3 – an observation which indicates site-specific differences in the underlying HA-related pathomechanisms along the anatomical course of the aorta. We hypothesise that locoregional responses to distinct stressors along the aorta are driven by the site-specific HA-rich matrix, thereby determining the heterogeneity in the development and progression of TAA and AAA/AAD.

透明质酸合成酶3（HAS 3）的基因缺失可改善血管紧张素II诱导的腹主动脉瘤和夹层（AAA/AAD）模型的存活率，因为Apoe-/-/Has 3-/-小鼠的血管破裂减少。此外，在不存在HAS 3的情况下未检测到胸主动脉瘤（TAA）-这一观察结果表明，主动脉解剖过程中沿着的潜在HA相关病理机制存在部位特异性差异。我们假设主动脉沿着对不同应激源的局部反应是由位点特异性富含HA的基质驱动的，从而确定了TAA和AAA/AAD发生和进展的异质性。