Biogenesis and activity-dependent dynamics of AMPA-receptor complexes (A08)

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Native AMPA-type glutamate receptors (AMPARs) are multi-protein complexes that reconsti-tute the receptor ion channels responsible for rapid signal transduction and memory formation in excitatory synapses of the mammalian brain. We will investigate the molecular steps behind assembly and processing of these multi-component machineries in the endoplasmic reticulum, analyze the structural details behind the complex assemblies, and study the significance of receptor dynamics for excitatory neurotransmission and its activity-dependent plasticity in the normal and diseased brain.