Biogenesis and activity-dependent dynamics of AMPA-receptor complexes (A08)

AMPA 受体复合物的生物发生和活性依赖性动力学 (A08)

• 批准号: 426828559
• 金额: --
• 依托单位: Lehrstuhl für Physiologie II - Molecular Physiology
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/426828559?language=en
• 关键词: Biogenesis; activity; dependent; dynamics; AMPA

Native AMPA-type glutamate receptors (AMPARs) are multi-protein complexes that reconsti-tute the receptor ion channels responsible for rapid signal transduction and memory formation in excitatory synapses of the mammalian brain. We will investigate the molecular steps behind assembly and processing of these multi-component machineries in the endoplasmic reticulum, analyze the structural details behind the complex assemblies, and study the significance of receptor dynamics for excitatory neurotransmission and its activity-dependent plasticity in the normal and diseased brain.

天然AMPA型谷氨酸受体（AMPA-type glutamate receptor，AMPAR）是哺乳动物脑内兴奋性突触中负责快速信号转导和记忆形成的受体离子通道的多蛋白复合物。我们将研究这些多组分机器在内质网中组装和加工背后的分子步骤，分析复杂组装背后的结构细节，并研究受体动力学对兴奋性神经传递及其在正常和患病大脑中的活性依赖性可塑性的意义。