Crosstalk between the mitochondrial respiratory chain and the cytosolic protein synthesis machinery (B05)

线粒体呼吸链和胞质蛋白质合成机制之间的串扰 (B05)

• 批准号: 426838103
• 金额: --
• 依托单位: Biozentrum der Universität Würzburg
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/426838103?language=en
• 关键词: Crosstalk; between; mitochondrial; respiratory; chain

Mitochondria fulfill important functions in cellular metabolism. The mitochondrial respiratory chain is essential for oxidation phosphorylation and dysfunction can lead to a drastic increase in reactive oxygen species. We showed that increased levels of mitochondria-produced reactive oxygen species result in a fast inhibition of the cytosolic protein synthesis machinery. In project B5, we will study the mechanisms underlying this important intracellular crosstalk and how translation is modulated. Our findings will contribute to a better understanding of mitochondrial dysfunction in human pathologies.

线粒体在细胞代谢中发挥重要作用。线粒体呼吸链对于氧化磷酸化是必不可少的，功能障碍可导致活性氧的急剧增加。我们发现，增加的水平，产生的活性氧自由基的结果在一个快速抑制的胞质蛋白质合成机器。在项目B5中，我们将研究这种重要的细胞内串扰的机制以及如何调节翻译。我们的研究结果将有助于更好地了解人类病理学中的线粒体功能障碍。