Interplay of the Hsp70 Ssb with ribosomes and cochaperones in the cytosol and at the ER membrane (B08)

Hsp70 Ssb 与细胞质和 ER 膜中核糖体和共伴侣蛋白的相互作用 (B08)

• 批准号: 426864344
• 金额: --
• 依托单位: Institut für Biochemie und Molekularbiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/426864344?language=en
• 关键词: Interplay; Hsp70; Ssb; ribosomes; cochaperones

The yeast Hsp70 chaperone Ssb and its J-protein partner RAC dynamically associate with ribosomes and assist in folding of nascent chains. We will study the mechanism of this interaction with idle and translating ribosomes and also include the so far poorly characterized nucleotide exchange factor Snl1. Furthermore, we will study the regulatory role of phosphorylation on the interplay of the ribosome-bound chaperones.

酵母Hsp70伴侣Ssb及其j蛋白伴侣RAC与核糖体动态结合并协助新生链折叠。我们将研究这种与空闲核糖体和翻译核糖体相互作用的机制，也包括迄今为止尚未表征的核苷酸交换因子Snl1。此外，我们将研究磷酸化对核糖体结合伴侣的相互作用的调节作用。