Assembly of PTH/polymer hybrid molecules (A12*)

PTH/聚合物杂化分子的组装 (A12*)

• 批准号: 427360171
• 金额: --
• 依托单位: Arbeitsbereich Technische Chemie und Makromolekulare Chemie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/427360171?language=en
• 关键词: Assembly; PTH; polymer; hybrid; molecules

The molecular ordering of reversibly aggregating parathyroid hormone conjugated to switchable synthetic polymers will be investigated. Amyloid assembly will be modulated by the switchable polymer upon external stimuli including temperature, solvent and light. Both, the protein and polymer entity will influence the properties of the hybrid partner allowing conformational studies and mechanistic insights into the assembly mechanism. These hybrid molecules harbor a wealth of physico-chemical properties, which we aim to understand based on fundamental principles.

将研究与可转换合成聚合物缀合的可逆聚集甲状旁腺激素的分子排序。淀粉样蛋白组装将在包括温度、溶剂和光的外部刺激下由可转换聚合物调节。蛋白质和聚合物实体都将影响混合伴侣的性质，从而允许构象研究和对组装机制的机械见解。这些混合分子具有丰富的物理化学性质，我们的目标是根据基本原理来理解。