唾液中分泌型IgAの女性における加齢との関連-生活状況および食生活を背景として-

唾液 IgA 与女性衰老的关系 - 在生活条件和饮食的背景下 -

• 批准号: 16650190
• 负责人: 松下 純子
• 金额: $ 1.86万
• 依托单位: Tokushima Bunri University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Exploratory Research
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16650190/
• 关键词: 老齢期女性; 免疫グロブリンA(IgA); 若年女性; 唾液; 食生活; 高齢女性

高齢化の進行が急速である今,加齢に伴う免疫力低下は周知の事実である。本研究では女性に注目し,年齢差による免疫能を捉えることを目的に唾液を採取し,分泌型IgA濃度を測定,生活状況,食生活についてアンケート調査を行い検討した。若年女性は大学2年女子学生58名,老齢期女性として昨年度は特養等に居住する者(以下在施設者)(平均84歳)30名,本年度は自宅に居住する者(以下在宅者)(平均79歳)14名を対象とした。唾液はキットを用い高齢女性3分間,女子大生3分間採取し,唾液量,IgA濃度,タンパク質量を測定,調査項目は生活状況,食生活等について確認した。在施設者と在宅者の調査結果はχ^2検定、測定値と各回答はt検定を行い検討した。高齢者の居住形態にかかわらず,唾液量は女子大生が有意に多く(1分間あたり),IgA量,タンパク質量は高齢女性の方が多い結果となり,高齢女性と若年女性の傾向が昨年度と一致した。女子大生では気分の良くない者は唾液量が少なく,気分の良否と唾液分泌との関連が推測された。栄養素量の摂取状況と各測定値には差が認められなかった。高齢女性では,唾液量,IgA量ともに在施設者と在宅者の間に大差はなかったが,在宅者は各値で個人差が大きく,残歯と唾液量の関連性は在施設者では認められたが,在宅者では認められなかった。総義歯率,杖,車いす使用は在施設者の方が高率を示した。睡眠時間は差がなかったが,よく眠ったという自覚は在施設者が有意に高率であった。肥満度による唾液量の相違は個人差が大きく,いずれの年代でも差が認められなかった。昨年度本年度を通じ,年齢の若い女子大生はIgA濃度の薄い唾液が多く分泌され,高齢女性は唾液のIgA濃度は濃く分泌量が少ないことが示唆された。高齢女性では全体の傾向は捉えたものの,在宅者では個人差が大きく,今後多くの要因を考慮する必要性のあることが判明した。

The progress of the high-grade treatment is rapid, and the high-grade treatment is accompanied by low immunity and low immunity. This study focuses on women, age difference, immune function, and the purpose of saliva collection. The secretory IgA concentration was measured, and the living conditions and dietary lifestyle were investigated. There are 58 female students in their second year of college, and 58 female students in their second year of university, senior female students, special care recipients of the previous year, and other residents (the following are those who are currently in the facility). There are 30 people (average age 84), and 14 people (average age 79) are currently living in their own homes (hereinafter living at home) (average age 79). Saliva samples were collected in 3 minutes from tall women and 3 minutes from college students. Saliva volume, IgA concentration, saliva quality, survey items, living conditions, food habits, etc. were all confirmed. The survey results of those who are constructing facilities and those who are staying at home are determined, the measured values ​​are determined, and each answer is determined. The living form of a tall person, the amount of saliva, the amount of saliva, the amount of saliva that a female college student has, the amount of IgA, The quality of the product is the same as the high-end women's side and the results are high, and the high-end women's tendencies are the same as the previous year's. It is speculated that the amount of saliva is small and the amount of saliva is small, and the relationship between saliva secretion and saliva secretion is speculated. The amount of nutrients is measured and the difference between each measured value is determined. The difference between tall and tall women, the amount of saliva, and the amount of IgA are the same between those who use facilities and those who stay at home, and those who stay at home have different values The correlation between individual differences and the amount of residual saliva depends on the condition of the provider and the condition of the person at home. The use of 総义毯, sticks, and carts is in the direction of the builder, and the high rate is shown in the tool. The sleep time is different, the sleeping time is good, and the sleep time is high due to the intention of the person doing it. The amount of saliva is inconsistent, the individual difference is large, and the age difference is different. Yesterday and this year, the IgA concentration of the current year was high, and the IgA concentration of the female college student was thin and the saliva was secreted. The general tendency of tall women is to catch the same, and the individual differences among those who live at home are very different. In the future, there will be many factors and the necessity will be considered and the necessity will be clearly understood.