Alveolar Ridge Preservation with Platelet Rich Fibrin (PRF) to avoid gingival clefts after orthodontic space closure

各种保存牙槽骨的技术，如拔牙后直接植入富血小板纤维蛋白(PRF)，已在牙科手术中得到应用。牙龈裂是拔牙后正畸缝隙关闭后常见的不良副作用，可被解释为拔牙后新生组织的形成与受累软硬组织的吸收之间的不利关系的结果。它们与正畸间隙关闭障碍、间隙重新开放可能导致牙间食物嵌塞、牙龈和牙周炎性反应增加以及额外的局部微生物定植有关。本项目旨在通过一项观察性研究，分析在正畸间隙关闭期间和之后，PRF对于避免或减少牙龈裂可能产生的积极影响。如果在拔牙槽中使用PRF可以有效地预防牙周裂，这可能会导致在日常实践中对正畸拔牙病例的手术程序提出建议。

Various techniques for alveolar ridge preservation, e. g. the insertion of platelet rich fibrin (PRF) directly after tooth extraction have been established in dental surgery. Gingival clefts are frequent, undesirable side-effects of orthodontic space closure after tooth extraction and can be interpreted as the result of an unfavorable relation between neo genesis and resorption of the involved hard and soft tissues in the area of tooth extraction. They are associated with an obstruction of orthodontic space closure, space re-opening that may cause interdental food impaction, increased gingival and periodontal inflammatory reactions as well as additional localized microbial colonization. This project aims to analyze a possible positive impact of PRF for the avoidance or reduction of gingival clefts during and after orthodontic space closure by means of an observational study. If the use of PRF in extraction sockets would show to be effective for the prevention of gingival clefts, this could lead to a recommendation for the surgical procedure in orthodontic extraction cases in daily practice.