Alveolar Ridge Preservation with Platelet Rich Fibrin (PRF) to avoid gingival clefts after orthodontic space closure

使用富血小板纤维蛋白 (PRF) 保留牙槽嵴，以避免正畸间隙闭合后出现龈裂

• 批准号: 427709178
• 负责人: Dr. Eric Kutschera
• 金额: --
• 依托单位: Poliklinik für Kieferorthopädie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/427709178?language=en
• 关键词: Alveolar; Ridge; Preservation; Platelet; Rich

Various techniques for alveolar ridge preservation, e. g. the insertion of platelet rich fibrin (PRF) directly after tooth extraction have been established in dental surgery. Gingival clefts are frequent, undesirable side-effects of orthodontic space closure after tooth extraction and can be interpreted as the result of an unfavorable relation between neo genesis and resorption of the involved hard and soft tissues in the area of tooth extraction. They are associated with an obstruction of orthodontic space closure, space re-opening that may cause interdental food impaction, increased gingival and periodontal inflammatory reactions as well as additional localized microbial colonization. This project aims to analyze a possible positive impact of PRF for the avoidance or reduction of gingival clefts during and after orthodontic space closure by means of an observational study. If the use of PRF in extraction sockets would show to be effective for the prevention of gingival clefts, this could lead to a recommendation for the surgical procedure in orthodontic extraction cases in daily practice.

牙槽嵴保存的各种技术，如拔牙后直接插入富血小板纤维蛋白（PRF）已在牙科手术中建立。龈裂是拔牙后正畸间隙关闭后常见的不良副作用，可解释为拔牙区受累的硬、软组织新生与吸收之间存在不利关系的结果。它们与正畸间隙关闭的阻塞有关，间隙重新打开可能导致牙间食物嵌塞，牙龈和牙周炎症反应增加以及额外的局部微生物定植。本项目旨在通过一项观察性研究，分析PRF在正畸间隙关闭期间和之后对避免或减少龈裂可能产生的积极影响。如果在拔牙槽中使用PRF可以有效地预防牙龈裂，这可能会导致在日常实践中推荐正畸拔牙病例的外科手术。