Elucidating protein-RNA interactions in circRNA biogenesis and function (A01)

阐明 circRNA 生物发生和功能中的蛋白质-RNA 相互作用 (A01)

• 批准号: 428016776
• 金额: --
• 依托单位: Institut für Kardiovaskuläre Regeneration
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/428016776?language=en
• 关键词: Elucidating; protein; RNA; interactions; circRNA

Circular RNAs (circRNAs) are generated by backsplicing and are abundantly expressed in many human tissues, yet their contribution to physiology and disease remains largely unknown. The aim of this project is to identify and characterise circRNA biogenesis and functions in endothelial cells. Specifically, we will study the function and mechanism of action of the previously identified circRNA cZNF292 and elucidate the regulation of circRNA biogenesis by combining bioinformatics with biochemical approaches and physiological assays.

环状RNA（circRNA）是通过反向剪接产生的，并且在许多人体组织中大量表达，但它们对生理学和疾病的贡献在很大程度上仍然未知。本项目的目的是鉴定和鉴定内皮细胞中的circRNA生物合成和功能。具体而言，我们将研究先前鉴定的circRNA cZNF 292的功能和作用机制，并通过生物信息学与生物化学方法和生理测定相结合来阐明circRNA生物合成的调控。