Elucidating protein-RNA interactions in circRNA biogenesis and function (A01)

环状rna （circRNAs）是由反剪接产生的，在许多人体组织中大量表达，但它们对生理和疾病的贡献在很大程度上仍然未知。该项目的目的是鉴定和表征内皮细胞中的circRNA生物发生和功能。具体而言，我们将通过生物信息学、生化方法和生理实验相结合的方法，研究先前鉴定的circRNA cZNF292的功能和作用机制，阐明circRNA生物发生的调控。

Circular RNAs (circRNAs) are generated by backsplicing and are abundantly expressed in many human tissues, yet their contribution to physiology and disease remains largely unknown. The aim of this project is to identify and characterise circRNA biogenesis and functions in endothelial cells. Specifically, we will study the function and mechanism of action of the previously identified circRNA cZNF292 and elucidate the regulation of circRNA biogenesis by combining bioinformatics with biochemical approaches and physiological assays.