FOR 926: Physiology and Pathophysiology of the Endocannabinoid System

FOR 926：内源性大麻素系统的生理学和病理生理学

• 批准号: 42860621
• 金额: --
• 依托单位: Institut für Physiologische Chemie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/42860621?language=en
• 关键词: 926; Physiology; Pathophysiology; Endocannabinoid; System

The term cannabinoids originally described the active ingredients in the hemp plant Cannabis sativa, including the well-known psychoactive substance ?9-Tetrahydrocannabinol (THC). THC activates the G-protein-coupled receptors CB1 and CB2. The physiological endogenous ligands of these receptors, the endocannabinoids, are lipids that are produced by many different cells. Recent results, to which the principle investigators of this Research Unit have contributed to a major extent, strongly suggests that the endocannabinoid system plays a crucial role in the physiological responses to internal and external stressors and thus contributes to the maintenance of the homeostasis. The short-term activation of the endocannabinoid system represents thus an important protective stress response and promotes the following protective physiological responses:

大麻素一词最初描述的是大麻植物Cannabis sativa中的活性成分，包括众所周知的精神活性物质？9-四氢大麻酚。THC激活G蛋白偶联受体CB1和CB2。这些受体的生理内源性配体，内源性大麻素，是由许多不同细胞产生的脂质。最近的研究结果，该研究单位的主要研究人员在很大程度上做出了贡献，强烈表明内源性大麻素系统在对内部和外部压力的生理反应中起着至关重要的作用，从而有助于维持稳态。因此，内源性大麻素系统的短期激活代表了重要的保护性应激反应，并促进了以下保护性生理反应：