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An experimental research on skull-surface recording of vestibular evoked potentials

头骨表面记录前庭诱发电位的实验研究

基本信息

批准号：
01480409
负责人：
UEMURA Takuya
金额：
$ 3.65万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480409/
关键词：
Evoked potential Rotatory stimulation Vestibular system Guinea pig Unit recording Labyrinthectomy

项目摘要

Rotational evoked potentials were studied in the guinea pig under urethane anesthesia. The stimulus events were triangular velocity changes produced by abrupt reversals of acceleration, and horizontal semicircular canals were stimulated. A positive-negative-positive (P_1-N_1-P_2) wave was recorded in the vestibular nuclei and the potential was totally abolished after bilateral labyrinthectomy. Single unit recordings revealed that the peak latency of the negative wave is almost coincident with the peak latency of the excitation of type I vestibular nucleus neurons. It is concluded that the recorded potential to the rotational stimuli in this experiment is of vestibular origin. P_1-N_1-P_2 waves similar to those in the Brainstem were recorded on the occipital portion of the cerebral surface and cerebellar surface. These waves were also abolished after bilateral labyrinthectomy. It is suggested that the vestibular evoked potentials is able to record on the brain surface.

在乌拉坦麻醉下对豚鼠进行了旋转诱发电位的研究。刺激事件是由加速度突然反向产生的三角形速度变化，刺激水平半规管。双侧前庭神经核可记录到正-负-正（P_1-N_1-P_2）波，双侧前庭神经核切除后，该电位完全消失。单单位记录显示，负波的峰潜伏期与前庭I型核神经元兴奋的峰潜伏期几乎一致。结论：本实验中记录到的旋转刺激电位是前庭电位。在大脑表面枕部和小脑表面记录到与脑干相似的P_1-N_1-P_2波。这些波也被取消后，双侧睾丸切除术。提示前庭诱发电位可在脑表面记录。