An experimental research on skull-surface recording of vestibular evoked potentials

研究了氨基甲酸乙酯麻醉豚鼠的旋转诱发电位。刺激事件是由加速度突然逆转引起的三角形速度变化，水平半规管受到刺激。双侧迷路切除后，前庭核出现正-负-正（P_1-N_1-P_2）波，电位完全消失。单单元记录显示，负波的潜伏期峰值与前庭I型核神经元兴奋的潜伏期峰值几乎一致。本实验记录的旋转刺激电位来源于前庭。枕部脑表面和小脑表面均可见与脑干相似的P_1-N_1-P_2波。双侧迷路切除术后，这些波也消失了。提示前庭诱发电位可以记录在脑表面。

Rotational evoked potentials were studied in the guinea pig under urethane anesthesia. The stimulus events were triangular velocity changes produced by abrupt reversals of acceleration, and horizontal semicircular canals were stimulated. A positive-negative-positive (P_1-N_1-P_2) wave was recorded in the vestibular nuclei and the potential was totally abolished after bilateral labyrinthectomy. Single unit recordings revealed that the peak latency of the negative wave is almost coincident with the peak latency of the excitation of type I vestibular nucleus neurons. It is concluded that the recorded potential to the rotational stimuli in this experiment is of vestibular origin. P_1-N_1-P_2 waves similar to those in the Brainstem were recorded on the occipital portion of the cerebral surface and cerebellar surface. These waves were also abolished after bilateral labyrinthectomy. It is suggested that the vestibular evoked potentials is able to record on the brain surface.