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EXPERIMENTAL STUDY ON HEPATIC ARTERIAL RECONSTRUCTION

肝动脉重建的实验研究

基本信息

批准号：
02454304
负责人：
KUMADA Kaoru
金额：
$ 3.58万
依托单位：
SHOWA UNIVERSITY (1991)Kyoto University (1990)
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454304/
关键词：
energy metabolism liver resection microsurgery heparin arterial keton body ratio hepatic artery lymphocyte Laser assisted anastomosis 病態肝肝移植肝動脈再建吻合部開存フィブリン糊

项目摘要

1. An experimental study on massive hepatectomy using rat and canine, revealed that patency of hepatic artery of the remnant liver did not influence their operative mortality, it did greatly restoration of energy metabolism and the mortality in jaundice or in transplantation model.2. i) Microsurgical technique is evidently useful for improved patency of reconstructed hepatic artery. ii) Heparin is more useful than antiplatelet drugs for maintenance of the patency. iii) Heparin remains useful for hepatic surgery although it influences value of arterial keton body ratio due to its lipolytic action.3. Rupture of the reconstructed site by contamination with digestive fluid was dominantly prevented by local administration of fibringlue in both interposition of venous graft and simple anastomosis of the rat artery, while combined use of collagen powder did not argument the preventive effect.4. The results that energy metabolism of lymphocyte, leukocyte or platelet reduced in 70% hepatectomized rat, leads to the assumption of reduced wound healing in massive hepatectomy.5. Results of Laser assisted anastomosis of the rat aorta was almost equal with the conventional. They reduced in the same rate by 70% hepatectomy, which suggested utility of Laser assisted anastomosis of the hepatic arterial reconstruction in liver surgery.

1.结论：1.大鼠和犬大面积肝切除的实验研究表明，残肝肝动脉的通畅对其手术死亡率无明显影响，但对黄疸和移植模型的能量代谢和死亡率有明显的恢复作用. i）显微外科技术对改善重建肝动脉的通畅性有明显作用。ii）肝素比抗血小板药物更有助于维持通畅性。3）肝素对肝脏手术仍然有效，尽管由于其脂解作用而影响动脉酮体比的值。在静脉移植和动脉单纯吻合中，局部应用明胶均能显著预防消化液污染引起的重建部位破裂，而联合应用胶原粉则无明显预防作用. 70%肝切除大鼠淋巴细胞、白细胞或血小板的能量代谢降低，提示了大面积肝切除术后伤口愈合速度减慢的假设.激光辅助吻合大鼠主动脉的效果与传统吻合方法相当。70%的肝切除术后，它们的减少率相同，这表明激光辅助吻合肝动脉重建在肝脏外科中的实用性。