Novel ligand synthesis for molecular recognition and analysis of the recognition systems

用于分子识别和识别系统分析的新型配体合成

• 批准号: 03453042
• 负责人: MATSUI Masakazu
• 金额: $ 4.42万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03453042/
• 关键词: molecular recognition; selective complex formation; bite size; beta-diketones; polypyrazyolyl borate; solvent extraction; separation chemistry; 分離; 剛直性配位子; 有機ヒ素; スペシエーション; 選択的配位子; ポリピラゾリルボレ-ト; アシルピラゾロン; 有機金属種; 錯出生反応

There is at present a need in several chemical fields toward ligand design for selectiv chelation of metals. And an understanding of the principles of selectivety would be invaluable in understanding the metal ion selectivity displayd by biological cation transport systems, metal ion binding proteins and how metal ions are distributed in the environment. The recognition concept proposed by us is as follows : The ion size recognition with conventional organic ligands is governed by a few parameters. The first is based on the distance between donor atoms, that is, bite size. And the second is the rigidity of the chelate ring.

目前，在几个化学领域中需要设计用于金属的选择性螯合的配体。了解选择性原理对于理解生物阳离子转运系统、金属离子结合蛋白所表现的金属离子选择性以及金属离子在环境中的分布具有重要意义。我们提出的识别概念是：常规有机配体对离子大小的识别受几个参数控制。第一种是基于施主原子之间的距离，即咬合尺寸。二是螯合环的刚性。

项目成果

N.Yasuda: "Solvent Extraction of Divalent Metals as Dihydrobis(1-pyrazolyl)borate Chelates." Bull.Chem.Soc.Jpn.65. 781-785 (1992)

N.Yasuda：“以二氢双（1-吡唑基）硼酸盐螯合物形式溶剂萃取二价金属。”

S.Umetani: "Precipitation and extraction of some bivalent metal ions with bis(diphenylphosphinyl)methane and perchlorate." Talanta. 38. 653-657 (1991)

S.Umetani：“用双（二苯基次膦基）甲烷和高氯酸盐沉淀和萃取一些二价金属离子。”

Yasumichi Nakai: "Nonaqueous Extraction of Zinc from Diethylene Glycol Solution Chloride by TOPO in Decaline" Bull.Inst.Chem.Res.,Kyoto Univ.68. 295-303 (1991)

Yasumichi Nakai：“通过 TOPO 在十氢化萘中从二甘醇氯化物溶液中非水萃取锌”Bull.Inst.Chem.Res.，Kyoto Univ.68。

Noriyasu Yasuda: "Solvent Extraction of Divalent Metals as Dihydrobis(1-pyrazoyl)borate Chelates" Bull.Chem.Soc.Jpn.65. 781-785 (1992)

Noriyasu Yasuda：“以二氢双（1-吡唑酰基）硼酸盐螯合物形式对二价金属进行溶剂萃取”Bull.Chem.Soc.Jpn.65。

松井 正和: "選択的分離分析のための配位子設計" ぶんせき. 3. 183-191 (1992)

Masakazu Matsui：“选择性分离分析的配体设计”Bunseki。3. 183-191 (1992)。