Clinical Significance of Brain Natriuretic Peptide (BNP) in Cardiac Diseases

脑钠肽（BNP）在心脏病中的临床意义

• 批准号: 03454218
• 负责人: MARUMO Fumitaki
• 金额: $ 2.56万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454218/
• 关键词: Brain natriuretic peptide; Atrial natriuretic peptide; Congestive heart failure; Myocardial infarction; BNP; ANP; ストレス; 心筋細胞; 発現調節; サイトカイン; 脳性Na利尿ペプチド(BNP); 心房性Na利尿ペプチド(ANP); 心不全; プロセシング

The objective of the present investigation was to clarify the clinical significance of brain natriuretic peptide (BNP) in various cardiac diseases compared to that of atrial natriuretic peptide (ANP). Plasma BNP levels in normal subjects were 2-4pg/ml, which were one-fifth those of ANP.However, under pathological conditions, such as hypertension, chrome renal failure, congestive heart distress syndrome, plasma BNP levels were remarkably elevated which exceeded those of ANP.Plasma BNP levels showed prognostic marker for cardiac deseases. While plasma ANP was derived from atria, plasma BNP was it is concluded that BNP is exclusively secreted from ventricle in response to acute stress. Which may function as one of the cardiac compensatory mechanisms to reduce both pre-and after load under the pathological states.

本研究的目的是阐明脑钠尿肽（BNP）与心房钠尿肽（ANP）相比在各种心脏病中的临床意义。正常人血浆BNP水平为2-4pg/ml，为ANP的五分之一。然而，在高血压、铬肾衰竭、充血性心力衰竭综合征等病理情况下，血浆BNP水平显着升高，超过ANP。血浆BNP水平是心脏病的预后标志。血浆 ANP 源自心房，而血浆 BNP 则源自心室，因此得出的结论是，BNP 完全由心室分泌，以应对急性应激。这可能是心脏代偿机制之一，可减轻病理状态下的前后负荷。

项目成果

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Kanno K：“白细胞介素在大鼠血管平滑肌细胞中诱导 NO 合酶基因”高血压。

Eguchi S.etal: "Effects of three distiuct natriwetic peptides on receptd binding and guanylate cyclase activaties in sotgliomacells" Eur.J.Pharmacol. 225. 79-82 (1992)

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Marumo F.etal: "Prolongation the kidney reserotion peuod by sinple wld atovage up to 72 hours by human atval ratvuretic peptsle" Tronsplautation. 51. 982-986 (1992)

Marumo F.etal：“通过人 atval 大鼠尿肽单次注射延长肾脏复位时间长达 72 小时”Tronsplautation。

Togashi K, et al.: "Brain natriuretic peptide in plasma, spinal cord and cere brospinal" Clin.Chin.Acta. 201. 193-200 (1991)

Togashi K 等人：“血浆、脊髓和脑脊髓中的脑钠尿肽”Clin.Chin.Acta。