Neurogenic control of brain edema

脑水肿的神经源性控制

• 批准号: 03454348
• 负责人: NAGAO Seigo
• 金额: $ 3.33万
• 依托单位: Kagawa Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454348/
• 关键词: Brain Edema; Cold Injury; Brain-stem Dysfunction; Arginine Vasopressin; V_1 Receptor Antagonist; Peptide Therapy; 抗脳浮腫効果; 神経性因子; 電気刺激; 中枢性バゾプレッシン; バゾプレッシン・レセプター・アンタゴニスト; ペプチド; バゾプレッシン・レセプタ-・アンタゴニスト

Using cats with cold brain injury, electrical stimulation of the medullary reticular formation for 40 minutes resulted in the increment of brain water content by 1.5 to 3.0% and arginine vasopressin (AVP) in the cerebrospinal fluid by two times. Recent reports indicate that central AVP facilitates movement of brain water in normal and pathological conditions. The experiments were carried out to clarify the therapeutic effect of AVP receptor antagonists on brain water in the condition of brain edema. Our results indicate that intraventricular administration of V_1 receptor antagonist of 50ng significantly reduces the increment of brain water content at the adjacent sites of the lesion associated with significant reduction of tissue Na^+ and increment of K^+. This beneficial effect was observed when AVP V_1 receptor antagonist was given prior to or after cold lesion to the brain. AVP V_2 receptor antagonist had less effect. AVP V_1 receptor antagonist may become effective therapy for brain edena.

电刺激延髓网状结构40分钟，可使脑含水量增加1.5 ~ 3.0%，脑脊液中精氨酸加压素（AVP）增加2倍。最近的研究表明，中枢AVP在正常和病理状态下促进脑水的运动。本实验旨在阐明AVP受体拮抗剂对脑水肿状态下脑水的治疗作用。结果表明，脑室注射V_1受体拮抗剂50 ng可明显降低脑损伤邻近部位脑组织含水量的增加，并使脑组织Na^+浓度显著降低，K^+浓度显著升高。在冷损伤前或冷损伤后给予AVP V_1受体拮抗剂均可观察到这一效应。AVP V_2受体拮抗剂作用较小。AVPV_1受体拮抗剂可能成为治疗脑水肿的有效药物。

项目成果

Tsuyoshi Kuniyoshi: "Role of stimulation of medullary reticular formation on centrally released arginine vasopressin in cold induced edema" Intracranial pressure VIII. VIII. 120-123 (1993)

Tsuyoshi Kuniyoshi：“刺激髓质网状结构对中央释放的精氨酸加压素在寒冷引起的水肿中的作用”颅内压VIII。

國吉 毅: "延髄網様体刺激による中枢性vasopressinの変化-脳浮腫の機序-" 脳浮腫研究会報告集. 13. 85-90 (1990)

Takeshi Kuniyoshi：“刺激髓质网状结构引起的中枢加压素的变化 - 脑水肿的机制 -” 脑水肿研究组的报告 13. 85-90 (1990)。

Masahiro Kagawa: "Treatment of vasogenic brain edema by V_1 receptor antagonist of arginine vasopressin" Recent Advances in Neurotraumatology. 264-267 (1993)

Masahiro Kakawa：“精氨酸加压素 V_1 受体拮抗剂治疗血管源性脑水肿”神经创伤学的最新进展。

Masahiro Kagawa: "Treatment of vasogenic brain edema by V_1 receptor antagonist of arginine vasopressin" Recent Advances in Neurotraumatology. VIII VIII. 264-267 (1993)

Masahiro Kakawa：“精氨酸加压素 V_1 受体拮抗剂治疗血管源性脑水肿”神经创伤学的最新进展。

Seigo Nagao: "Effect of stimulation of the medullary reticular formation on centrally released arginine vasopressin in cold induced edema" Advances in Experimental Neurotrauma Research. 2. 82-86 (1990)

Seigo Nagao：“刺激髓质网状结构对冷诱导水肿中集中释放的精氨酸加压素的影响”实验神经创伤研究进展。