HTLV-I and the eye

本文从临床和基础两方面对人类嗜t淋巴病毒1型（HTLV-I）相关的眼部问题进行了研究，得到以下结果：发现HTLV-I作为全身性疾病的一部分或作为孤立的眼部疾病，其病因与明显的眼部疾病有关。两种眼部疾病是明显的，即htlv - 1相关性葡萄膜炎（hau0）和htlv - 1相关性视网膜脉络膜变性。HTLV-I相关性葡萄膜炎（HAU）。HTLV-I相关脊髓病患者或HTLV-I携带者可出现葡萄膜炎症体征和症状。临床表现为前段或后段急性肉芽肿性炎症，经皮质类固醇治疗后消退。视力结果通常良好，但经常复发。htlv - 1相关性视网膜脉络膜变性（HARD）。这种病理偶见于htlv - 1相关脊髓病患者，其特征与遗传性变性相似。HTLV-I抗体的眼内合成。HAU患者的水体液显示眼内产生HTLV-I抗体的证据，而少数病例在房水中显示HTLV-I的前病毒DNA，这表明HAU代表免疫应答结果，而不是逆转录病毒的眼部感染。患者HLA研究提示HAU的免疫遗传学背景。

We studied ocular problems relevant to human T-lymphotropic virus type 1 (HTLV-I).from cliical and basic viewpoints and the following results were obtained. Distinct ocular disorers were found to occur with etiological association to HTLV-I as a part of systemic diseases or as an isolated ocular disease. Two ocular disorders are noticeable, that is HTLV-I associated uveitis (HAU0and HTLV-I associated retinochoroidal degeneration.1. HTLV-I associated uveitis (HAU). Uveal inflammatory signs and symptoms are developed in patients with HTLV-I associated myelopathy or in HTLV-I carriers., with clinical features consisting of acute granulomatous inflamations in the anterior or posterior segments which resolve in response to corticosteroids. Visual outcome is usually favorable, but recurrent disease is frequent.2. HTLV-I associated retinochoroidal degeneration (HARD). This pathology is found in occasional patients with HTLV-I associated myelopathy, with features similar to hereditary degeneration.3. Intraocular synthesis of antibodies to HTLV-I.Aqueous humors from patients with HAU showed evidence of intraocular production of antibodies to HTLV-I while few cases showed proviral DNA of HTLV-I in the aqueous humor, suggesting that HAU represents immune response results rather than ocular infection of the retrovirus.4. Immunogenetic background of HAU was suggested from HLA studies in patients.