Suppression of diabetes by serum thymic factor

血清胸腺因子抑制糖尿病

• 批准号: 04454116
• 负责人: ONODERA Takashi
• 金额: $ 4.03万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454116/
• 关键词: interferon; pseudorabies virus; serum thymic factor; macrophage; NK cell; macrophage activity; anti-asialo GM1; VSV; 1型糖尿病

Susceptibility to pseudorabies virus (PRV) infection in mice, which were continuously depleted of natural killer (NK) cell activity by injection of anti-asialo GM1, was examined. Effects of serum thymic factor (FTS) on susceptibility of mice to PRV were also investigated. In mice with depleted NK cell activity, the mortality of PRV-infected mice was markedly high, whereas that of FTS-pretreated mice was significantly lower than the controls. Reduced susceptibility to PRV was demonstrated in mice treated with anti-asialo GM1 antisera before the PRV infection. Such a reduced susceptibility was not observed in mice inoculated with the antisera on day 1 post-infection. To analyze the FTS-induced resistance to PRV infection, NK cell activity, macrophage activity, and interferon (IFN) productions were studied. Interferon production and NK cell activity were enhanced in the FTS-pretreated mice, suggesting that interferon may play an important role in this FTS-induced resistance to PRV infection.

通过注射抗去唾液酸GM1，检测了小鼠对伪狂犬病病毒（PRV）感染的易感性，小鼠的自然杀伤（NK）细胞活性持续耗竭。研究了血清胸腺因子（FTS）对PRV易感性的影响。在NK细胞活性耗尽的小鼠中，PRV感染小鼠的死亡率明显较高，而FTS预处理小鼠的死亡率明显低于对照组。在PRV感染前用抗去唾液酸GM1抗血清处理的小鼠中证明了对PRV的敏感性降低。在感染后第1天接种抗血清的小鼠中未观察到这种降低的易感性。为了分析FS诱导的对PRV感染的抗性，研究了NK细胞活性、巨噬细胞活性和干扰素（IFN）产生。干扰素的产生和NK细胞的活性增强，表明干扰素可能发挥重要作用，在这种FS诱导的抵抗PRV感染。

项目成果

Shibata, I., Segami, Y.and Onodera, T.: "A serological survey on encephalomyocarditis virus infection of pigs in Japan." J.Vet.Med.Sci.55. 117-118 (1993)

Shibata, I.、Segami, Y. 和 Onodera, T.：“日本猪脑心肌炎病毒感染的血清学调查”。

Onodera, T., Ikeda, T., Tada, T., Taniguchi, M.(Eds.): Menekikougaku no shinpo.Igakusyoin, 230 (1993)

Onodera, T.、Ikeda, T.、Tada, T.、Taniguchi, M.（编）：Menekikougaku no shinpo.Igakusyoin，230（1993）

湯川真嘉 他5名: "Protective effects of serum thymic factor against leptospira interrogans serovar infection in mongolian gerbils." Vet.Microbiol.11(3) (印刷中). (1994)

Maki Yukawa 和其他 5 人：“血清胸腺因子对蒙古沙鼠问号钩端螺旋体血清感染的保护作用。Vet.Microbiol.11(3)（出版中）。”

湯川 真嘉: "Protective effects of serum thymic factor against leptospira interrogans serovar infection in mongolian gerbils." Vet.Microbiol.11(3)(印刷中). (1994)

Maki Yukawa：“血清胸腺因子对蒙古沙鼠问号钩端螺旋体血清型感染的保护作用。Vet.Microbiol.11(3)（出版中）。”

Onodera, T., Yoshihara, K., Suzuki, T., Awaya, A., Kobayashi, H.and Yukawa, M.: "Resistance to pseudorabies virus with enhanced interferon production and natural killer cell activity in mice treated with serum thymic factor in mice." Microbiol.Immunol.38.

Onodera, T.、Yoshihara, K.、Suzuki, T.、Awaya, A.、Kobayashi, H. 和 Yukawa, M.：“用血清胸腺治疗的小鼠对伪狂犬病病毒的抵抗力增强，干扰素产生和自然杀伤细胞活性增强