Effect of Continuous Intraarterial Infusion of Vasodilator and Anticoagulant to Extend the Survial of a Pedicled Flap Through Unusual Routes in Rabbit

持续动脉内输注血管扩张剂和抗凝剂对延长家兔异常途径带蒂皮瓣存活率的影响

• 批准号: 04454314
• 负责人: MATSUO Kiyoshi
• 金额: $ 4.29万
• 依托单位: SHINSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454314/
• 关键词: FLAP; SURVIVAL LENGTH; CONTINUOS INTRAARTERIAL INFUSION; VASODILATOR; ANTICOAGULANT

When a pedicled flap is extended over the safety length, the distal portion of the flap may necrose. To safely extend the survival length of the flap, surgical delay, intravenous and intraarterial administration of vasodilators and anticoagulants have been performed. As the intraarterial administration in flap surgery has a risk of thromboembolism, it has been rarely reported. In our experimental rabbit model, to preserve the main arterial inflow to the flap and to reduce the risk of thromboembolism, the infusion of PGE_1 was administered via a upstream branch of the nutrient artery in retrograde fashion, or via a nutrient artery of next neighbor vascular territory in the extended portion of the flap in advance fashion. Results showed that both the former and the latter route increases the vascularity and the survial length of the flap. In conclusion, it is important keeping anticoagulant condition in the flap until the revascularization between the flap and recipient site occurs as well as increasing vascularity, to extend the survival length of the flap.

当带蒂皮瓣延伸超过安全长度时，皮瓣的远端部分可能坏死。为了安全地延长皮瓣的存活长度，手术延迟，静脉和动脉内血管扩张剂和抗凝剂的管理已被执行。由于皮瓣手术中动脉内给药存在血栓栓塞的风险，因此很少有报道。在我们的实验兔模型中，为了保留皮瓣的主要动脉流入并减少血栓栓塞的风险，通过逆行方式经滋养动脉的上游分支或通过皮瓣延伸部分的相邻血管区的滋养动脉提前注入PGE_1。结果表明，前、后两种入路均能增加皮瓣血供，延长皮瓣成活长度。结论：在皮瓣与受区之间血运重建前，保持皮瓣内抗凝状态，增加血供，是延长皮瓣成活的重要措施。

项目成果

Kiyoshi Matsuo,et al: "Continuous Intraarterial Infusion of Prostaglandin E_1 and Heparin to Extend and Imprae the Survival of Pedicled Musalocutaneous Flaps through Unusual Routes:A Clinical Preliminary Report" Annals of Plastic Surgery. 29. 314-320 (199

Kiyoshi Matsuo 等人：“通过不寻常途径连续动脉内输注前列腺素 E_1 和肝素以延长和影响带蒂肌皮瓣的存活：临床初步报告”整形外科年鉴。

松尾清, (波利井清紀,鳥居修平編): "皮弁移植法:最近の進歩 持続動注による皮弁拡大と安全性向上の試み" 克誠堂出版 東京, 224 (17-22) (1993)

Kiyoshi Matsuo，（Kiyonori Harii、Shuhei Torii eds.）：“皮瓣移植方法：最新进展：尝试使用连续动脉内输注来扩大皮瓣并提高安全性”Kuseido Publishing Tokyo，224（17-22）（1993）

Kiyoshi Matsuo et al.: "Continuous Intraarteria Infusion of Prostaglandin E_1 and Heparin to Extend and Improve the Survival of Pedicled Musculocutanous Flaps Through Unusual Route : A Cinical Preliminary Report" Ann.Plast.Surg.19. 314-320 (1992)

Kiyoshi Matsuo 等人：“通过不寻常的途径连续动脉内输注前列腺素 E_1 和肝素以延长和改善带蒂肌肉皮瓣的存活：临床初步报告”Ann.Plast.Surg.19。

松尾清-波利井清他.鳥居修平編著: "皮弁移植法-最近の進歩-持続動注による皮弁拡大と安全性向上の試み" 克誠堂出版株式会社, 6/224 (1993)

Kiyoshi Matsuo、Kiyoshi Harii 等、Shuhei Torii（编）：“皮瓣移植 - 最新进展 - 通过连续动脉注射扩大皮瓣并提高安全性的尝试” Kuseido Publishing Co., Ltd.，6/224（ 1993）

松尾清-波利井清紀・鳥居修平編著-: "皮弁移植法-最近の進歩-持続動注による皮弁拡大と安全性向上の試み" 克誠堂出版株式会社, 6-224 (1993)

Kiyoshi Matsuo - Kiyonori Harii 和 Shuhei Torii（编辑）：“皮瓣移植 - 最新进展 - 通过连续动脉输注进行皮瓣扩张和安全性改进的试验” Kuseido Publishing Co., Ltd.，6-224 (1993)