Computational Fluid Mechanics of the Blood Flow

现在已经确定，血流的力学特性与各种血管疾病（如动脉粥样硬化）的发生、定位和发展密切相关。需要解决的问题是，在这些病理过程中，血流的何种力学现象或性质起着关键作用。我们对血流与血管壁之间的相互作用进行了系统的计算流体力学分析。在这项拨款的帮助下，研究了以下主题：动壁面流场分析。(1)左心室。(2)动脉狭窄伴壁厚。主动脉分叉、冠状动脉痉挛等复杂三维几何血管血流可视化。细胞尺度的计算流体力学。计算并分析了体外培养的动脉内皮细胞的壁剪应力。总之，血流场的三维特征在分析血流与壁面运动之间的相互作用中是至关重要的。利用新的计算方法对壁面力学进行进一步的研究。

It is now firmly established that the mechanical characteristics of the blood flow deeply concerns with the initiation, localization, and the development of various vascular disorders, such as atherosclerosis. The problem to be solved is what kind of mechanical phenomena or properties of the blood flow plays a key role in these pathological processes. We carried out a systematic computational fluid mechanical analysis of the interactions between the blood flow and the vessel wall. Following subjects were studied by the aid of this grant ;1. Analysis of the flow field with moving walls.(1) Left ventricle of the heart.(2) Arterial stenosis with a thick wall.2. Visualization of the blood flow in the vessels with complex three dimensional geometry, such as aortic bifurcation, coronary spasm, etc.Computational fluid mechanica of the cellular scale.The wall shear stress over the cultured arterial endothelial cells was computed and analyzed. In conclusion, the three dimensional characteristics of the blood flow field was shown to be crucial in the analysis of the interactions between the blood flow and the wall motion. The wall mechanics should be further studied with respect to the blood flow inside using new computational method.