Mechanism and regulation of hypercalcemia in adult T-cell leukemia

成人T细胞白血病高钙血症的机制及调控

基本信息

项目摘要

We have proposed that highly associated hypercalcemia in adult T-cell leukemia (ATL) may be induced by synergetic effects of interleukin-1 production through a vicious cycle and PTHrP production from ATL cells.In this study, the new following findings were obtained in ATL.1. PTHrP production, mRNA expression and the growth of ATL cells were rather enhanced in cell culture system under abnormally high levels of calcium condition (up to 4mM) suggesting that there may be another vicious cycle in hypercalcemia of ALT.2. IL-2 increased PTHrP production in culture nedia. In contrast, IL-4 which is known to be one of bone resorption inhibiting factor decreased mRNA expression of potent bone resorption stimulating factor (BRSF), IL-6, suggesting that various kind of cytokines may be involved in enhancement or inhibition of hypercalcemia of ATL.3. It was demonstrated that osteoblastic cells adhered to ATL cells, and ATL cells adhered homotypically througha the expression of various kinds of cellular adhesion molecles on the cell surface. Subsequently, these cellular adhesion induced the production of IL-1 and IL-6, very potent BRSF,suggesting that cell-cell adhesion may be involved in the induction of hypercalcemia in ATL as an additional important key.4. The proliferation of ATL cells and PTHrP production from ATL cells were inhibited by an analog of V.D3 (OCT). Also, it was confirmed that IL-4 inhibited hypercalcemia and decreased the number of osteoclasts in in-vivo experiment. These results suggest that OCT and IL-4 may be usuful candidates for the inhibition of malignant hypercalcemia.
我们提出成人T细胞白血病(ATL)高钙血症可能是由ATL细胞产生白细胞介素-1(IL-1)和PTHrP的恶性循环协同作用引起的。在异常高钙条件(高达4 mM)下,细胞培养系统中ATL细胞的PTHrP产生、mRNA表达和生长均明显增强,这表明ALT高钙血症可能存在另一种恶性循环。2. IL-2增加培养细胞PTHrP的产生。相反,骨吸收抑制因子IL-4可降低骨吸收刺激因子(BRSF)IL-6的mRNA表达,提示多种细胞因子可能参与了ATL高钙血症的增强或抑制。结果表明,成骨细胞与ATL细胞之间存在粘附,且ATL细胞通过细胞表面多种细胞粘附分子的表达而形成均一性粘附。随后,这些细胞粘附诱导IL-1和IL-6的产生,非常有效的BRSF,提示细胞-细胞粘附可能是参与诱导ATL高钙血症的另外一个重要关键. V.D3类似物(OCT)可抑制ATL细胞的增殖和PTHrP的产生。此外,在体内实验中证实了IL-4抑制高钙血症并减少破骨细胞的数量。这些结果表明OCT和IL-4可能是抑制恶性高钙血症的有用候选物。

项目成果

期刊论文数量(62)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tanaka,Y: "Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocyte" Immunol.Today. 14. 111-115 (1993)
Tanaka,Y:“内皮细胞上的蛋白聚糖向白细胞呈现粘附诱导细胞因子”《今日免疫》。
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Mori,Naoki: "Enhancing effect of interleukin-2 on production of parathyroid hormone-related protein by adult T-cell leukemia cells" Japanese Journal of Cancer Research. 84. 425-430 (1993)
Mori, Naoki:“白细胞介素 2 对成人 T 细胞白血病细胞产生甲状旁腺激素相关蛋白的增强作用”日本癌症研究杂志。
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江藤 澄哉: "悪性腫瘍における高カルシウム血症" 腎と骨代謝. 7. 167-178 (1994)
Sumiya Eto:“恶性肿瘤中的高钙血症”《肾脏和骨代谢》7. 167-178 (1994)。
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Shirakawa,Fumihiko: "The human prointerleukin 1beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific-induction" Molecular Cellular Biology. 13. 1332-1344 (1993)
Shirakawa, Fumihiko:“人类白细胞原 1β 基因需要转录起始位点近端和远端的 DNA 序列来进行组织特异性诱导”《分子细胞生物学》。
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Mori,Naoki: "Enhancing effect of interleukin-2 on production of pararhyroi hormone-related protein by aduit T-cell leukemia cells" Japanese Journal of Cancer Reseasch. 84. (1993)
Mori, Naoki:“白细胞介素 2 对成年 T 细胞白血病细胞产生副甲状腺激素相关蛋白的增强作用”日本癌症研究杂志。
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ETO Sumiya其他文献

ETO Sumiya的其他文献

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{{ truncateString('ETO Sumiya', 18)}}的其他基金

(Specific Regulation of Mechanism of Hypercalcemia Induction in Adult T Cell Leukemia.)
(成人T细胞白血病高钙血症诱导机制的具体调控。)
  • 批准号:
    09470226
  • 财政年份:
    1997
  • 资助金额:
    $ 3.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of transcriptional factors which are responsible for the expression of inflammatory cytokines in rheumatoid arthritis synovial cells.
分析负责类风湿性关节炎滑膜细胞中炎症细胞因子表达的转录因子。
  • 批准号:
    07807053
  • 财政年份:
    1995
  • 资助金额:
    $ 3.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effect of interleukin 1 and PTH related protein on hypercalcemia in adult T-cell leukemia
白细胞介素1及PTH相关蛋白对成人T细胞白血病高钙血症的影响
  • 批准号:
    01480221
  • 财政年份:
    1989
  • 资助金额:
    $ 3.9万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Immunosuppressive factors produced by adult T cell leukemia (ATL) cells and its relation to ATL induction
成人 T 细胞白血病 (ATL) 细胞产生的免疫抑制因子及其与 ATL 诱导的关系
  • 批准号:
    61480185
  • 财政年份:
    1986
  • 资助金额:
    $ 3.9万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

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