Regulation of coronary circulation or pulmonary circulation in the setting of simulated space environments.

在模拟空间环境中调节冠脉循环或肺循环。

• 批准号: 05454276
• 负责人: OGAWA Satoshi
• 金额: $ 4.16万
• 依托单位: KEIO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454276/
• 关键词: Space; Gravity; Systemic circulation; Coronary circulation; Pulmonary circulation; ventilation; perfusion imbalance; EDRF

To simulate the space environment, the animals were tilted down by 10degrees.The chronically instrumented dog enabled us to measure coronary blood flow continuously were studied.In the setting of simulated space environment, there was no discernible change in coronary flow reserve assessed by reactive hyperemia created with 20-second occlusion.Although there was little increase in left ventricular volume in the setting of the simulated space environment, the blockade resulted in the augmented response of left ventricular volume to the head-down tilt.This augmentation caused the marked increase in coronary blood flow.This was probably due to increase in oxygen demand of the heart in the setting of simulated space environment.Acetylcholine induced systemic hypotension.This response was partially inhibited by 1-Nitro Arginine Methyl Ester (1-NAME), and was completely inhibited by mucarinic-1 receptor blockade (Pirenzepine).On the other hand, the response of coronary arterial resistance to acetylcholine was hardly inhibited by 1-NAME and strongly inhibited by Pirenzepine.To clarify the effect of high-gravity condition on pulmonary circulation, the determination of EDRF was established and the effects of low alveolar oxygen on the gravity dependent distribution of pulmonary blood flow were studied.Low alveolar oxygen redistributed the blood flow from lower lung field to upper lung field.

为了模拟太空环境，动物被倾斜10度。我们研究了能够连续测量冠状动脉血流量的慢性仪器狗。在模拟太空环境的设置中，通过20秒阻塞造成的反应性充血评估的冠状动脉血流储备没有明显的变化。尽管在模拟太空环境的设置中左心室容积几乎没有增加，结果表明：1-硝基精氨酸甲酯（1-NAME）可部分抑制乙酰胆碱引起的低血压反应。并被粘蛋白-1受体阻断剂完全抑制另一方面，冠状动脉阻力对乙酰胆碱的反应几乎不被1-NAME抑制，而被哌仑西平强烈抑制。建立了EDRF测定方法，研究了低肺泡氧对肺血流重力依赖性分布的影响，发现低肺泡氧使肺血流由下肺野向上肺野重新分布。

项目成果

Akaishi,M.: "Acute myocardicl infarceion without warning:clinical characteristios and significance of preinfarction angina" Coidiology. 82. 242-247 (1993)

Akaishi，M.：“无预警的急性心肌梗死：梗死前心绞痛的临床特征和意义” Coidiology。

Ogawa,S.et al.: "Effect on short-term prognosis and left ventricular function of angina pectoris prior to first Q-wave anterior wall acute myocardial infarction." Am J Cardiol. 74. 755 (1994)

Okawa,S.et al.：“首次 Q 波前壁急性心肌梗死之前的心绞痛对短期预后和左心室功能的影响。”

Ogawa S,et al.: "Sympathetic denervation of the epicardial border zone on the genesis of dispersion of refractoriness and arrhythmogenesis in a 7-day-old canine myocardial infarction model." Coronary artery disease. 4. 775-782 (1993)

Okawa S 等人：“心外膜边界区去交感神经支配对 7 日龄犬心肌梗死模型中不应性分散和心律失常发生的影响。”

Ogawa S et al.: "Effect on short-term prognosis and left ventricular function of angina pectoris prior to first Qwave anterior wall acute myocardial infarction." Am J Cardiol. 74. 755-759 (1994)

Okawa S 等人：“首次 Q 波前壁急性心肌梗死之前的心绞痛对短期预后和左心室功能的影响。”

Yamaguchi,K.: "Regulation of blood flow in pulmonary microcirculation by vasoactive arachidonic acid metabolites - Analysis in acute lung injery" Adu,Lyp Med.Biol. 345. 113-120 (1994)

Yamaguchi,K.：“血管活性花生四烯酸代谢物对肺微循环血流的调节 - 急性肺损伤的分析”Adu，Lyp Med.Biol。