权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A physiological and biochemical study on the sports anemia

运动性贫血的生理生化研究

基本信息

批准号：
05670076
负责人：
TAMURA Akira
金额：
$ 1.34万
依托单位：
Chukyo Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

A participation of plasma free fatty acid as a inducer on a sports anemia was investigated, and preventive measures on the anemia from nutritional point of view was discussed. The results obtained here are as follows ;1) The concentration of a plasma free fatty acid increased with moderate exercise (running, about 50% of VO_<2max>) for 30 min than the hard exercise (85% of VO_<2max>). After the moderate exercise at a fast state (respiratory quotient (RQ) of 0.77), a marked elevation of the plasma fatty acid was observed (1.70 <plus-minus> 0.48 mM,maximum value : 2.7mM). However, little elevation of plasma fatty acid was observed under normal diet (RQ ; 0.87) after same level of exercise (0.57 <plus-minus> 0.24 mM).2) A kind of fatty acid increased in a plasma after the moderate exercise was oleic, palmitic, linoleic, palmitoleic or arachidonic acid (ratio ; 20 : 15 : 10 : 3 : 2, respectively). When a mixture of fatty acids increased in the plasma was added to the normal whole blood in vitro, an erythrocyte shape changed from a normal discocyte to an echinocyte. A filtrability of the cells was measured by using hemafilmembrane having a pore of 5 um in diameter. The filtration rate of the shape altered-cell was significantly decreased. The result implies that a free fatty acids incorporated into the erythrocyte membrane reduce the deformability of the cells.3) A haptoglobin concentration in a plasma of a marathon runner was markedly reduced after only half day training. A decrease in haptoglobin in a plasma indicates the hemolysis causing in the blood vessel.4) These results suggest that the sports anemia derived by destruction of the erythrocytes may be caused by the plasma free fatty acids which are hydrolyzed by hormon (catecholamine) sensitive lipase. A proper uptake of energy sources before training seems to be important, in order to suppress an excessive production of free fatty acid resulting in erythrocyte destruction.

本文探讨了血浆游离脂肪酸作为运动性贫血诱发因素的参与，并从营养学角度探讨了运动性贫血的预防措施。结果表明：（1）中等强度运动（跑步，约占VO_2的50%）30 min时，血浆游离脂肪酸浓度<2max>比剧烈运动（占VO_2的85%）时升高<2max>;在快速状态（呼吸商（RQ）为0.77）的中度运动后，观察到血浆脂肪酸的显着升高（1.70 - <plus-minus>0.48 mM，最大值：2.7 mM）。2）中等强度运动<plus-minus>后血浆中脂肪酸含量增加的种类为油酸、棕榈酸、亚油酸、棕榈油酸和花生四烯酸（比例分别为20：15：10：3：2）。当在体外将血浆中增加的脂肪酸混合物加入正常全血中时，红细胞形状从正常盘状细胞变为棘状细胞。通过使用具有直径为5 μ m的孔的hemafilmembrane测量细胞的过滤性。变形细胞的滤速明显降低。结果表明，掺入红细胞膜的游离脂肪酸降低了细胞的变形性。3）仅在半天训练后，马拉松运动员血浆中的结合珠蛋白浓度显著降低。血浆中结合珠蛋白的减少表明在血管中引起溶血。4）这些结果表明红细胞破坏引起的运动性贫血可能是由血浆游离脂肪酸被激素（儿茶酚胺）敏感的脂肪酶水解引起的。在训练前适当摄取能量来源似乎很重要，以抑制导致红细胞破坏的游离脂肪酸的过度产生。