Role of prostaglandin in gastric and pancreatic secretion regulated by gastrointestinal hormones.

前列腺素在胃肠激素调节的胃和胰腺分泌中的作用。

• 批准号: 05670501
• 负责人: SHIRATORI Keiko
• 金额: $ 1.22万
• 依托单位: Tokyo Women's Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670501/
• 关键词: SECRETIN; CHOLECYSTOKININ; SOMATOSTATIN; PROSTAGLANDIN; GASTRIC ACID; EXOCRINE PANCREAS; INDOMETHACIN; 膵外分泌; 遊離膵腺房

Role of endogenous prostaglandins in (1) gastric and (2) pancreatic secretion regulated by gastrointestinal hormones was studied in the rat.1. Inhibitory action of secretin and somatostatin on gastrin-stimulated gastric acid secretion was studied with or without a prostaglandin synthesis inhibitor, indomethacin, treatment in the rat prepared with the perfused stomach. Indomethacin completely blocked secretin-induced inhibition of gastric acid secretion.In addtion, secretin significantly increased prostaglandin conctent in the gastric mucosa. However, somatostatin failed to do so. In conclusion, the inhibitory action of secretin on gastric acid secretion is mediated by endogenous prostaglandins, and the mechanism inhibiting acid secretion of somatostatin is different from secretin.2. Stimulatroy action of secretin and cholecystokinin (CCK) on pancreatic exocrine secretion was studied with or without indomethacin in vivo in rats. Indomethacin unaffected the stimulatory effect of both hormones on pancreatic secretion. It is unlikely that endogenous prostaglandins play a significant role on pancreatic secretion stimulated by these hormones. To confirm the result in vitro, we are doing further experiments whether or not amylase release in response to CCK is influenced by indomethacin in isolated pancreatic acini at the present time.

研究了内源性前列腺素在大鼠胃肠激素调节的(1)胃和(2)胰腺分泌中的作用。研究了前列腺素合成抑制剂吲哚美辛对胃灌注大鼠胃泌素刺激下胃酸分泌的抑制作用。吲哚美辛完全阻断分泌素诱导的胃酸分泌抑制。此外，分泌素显著增加胃黏膜前列腺素含量。然而，生长抑素却没有做到这一点。综上所述，分泌素对胃酸分泌的抑制作用是由内源性前列腺素介导的，生长抑素抑制胃酸分泌的机制与分泌素不同。用吲哚美辛和不加用吲哚美辛研究了分泌素和胆囊收缩素（CCK）对大鼠胰腺外分泌的刺激作用。吲哚美辛不影响两种激素对胰腺分泌的刺激作用。内源性前列腺素不太可能在这些激素刺激的胰腺分泌中起重要作用。为了在体外证实这一结果，目前我们正在进一步研究吲哚美辛是否影响离体胰腺腺泡对CCK的淀粉酶释放。

项目成果

Shiratori K: "Differential effects of intraduodenal medium-and long-chain triglyceride on pancreatic secretion and CCK release in rats." Gastroenterology. 104. A357- (1993)

Shiratori K：“十二指肠内中链和长链甘油三酯对大鼠胰腺分泌和 CCK 释放的不同影响。”

Shiratori K: "Role of endogenous prostaglandins in secretin- and plaunotol- induced inhibition of gastric acid secretion in the rat." American Journal of Gastroenterology. 88. 84-89 (1993)

Shiratori K：“内源性前列腺素在促胰液素和普劳诺醇诱导的大鼠胃酸分泌抑制中的作用。”

白鳥敬子: "脂肪消化障害の膵外分泌,消化管ホルモンに及ぼす影響" 日本膵臓学会誌. 9. 47 (1994)

Keiko Shiratori：“脂肪消化紊乱对胰腺外分泌和胃肠激素的影响”日本胰腺学会杂志 9. 47 (1994)。

白鳥敬子: "ガストリン、胃酸分泌抑制における腸管内脂肪消化と膵液の役割." 消化管ホルモン. (XII). 15-18 (1993)

Keiko Shiratori：“胃泌素，肠道脂肪消化和胰液在抑制胃酸分泌中的作用”（XII）。

白鳥敬子: "膵液病学:膵の分泌機構" 竹内正, 567 (1993)

Keiko Shiratori：“胰液病理学：胰腺的分泌机制”Tadashi Takeuchi，567（1993）