The significance of the low molecular fraction of house dust mite on allergic diseases
The significance of the low molecular fraction of house dust mite on allergic diseases
批准号:
05670657
负责人:
MORIKAWA Akihiro
金额:
$0.96万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1994
中文摘要
用凝胶层析法对室内尘螨(Dermatophagoides farinae, Df)进行了纯化,发现Df的低分子量组分(Df- lmw)含有5个组分,这些组分含有大量的糖。10Kd下的Df-LMW可能是富含糖的半抗原物质,这些与特应性皮炎有关。我们将利用表达载体制备重组Df-LMW。rf - lmw可能参与变态反应性疾病的发病机制和治疗。
英文摘要
By purification of house dust mite (Dermatophagoides farinae, Df) using gel chromatography, it revealed that low molecular weight fraction (Df-LMW) of Df contained five fractions and these fraction contain much sugar. Df-LMW under the 10Kd might be sugar rich haptenic substance and these and atopic dermatitis.We are going to make recombinant Df-LMW using expression vector. rDf-LMW may contribute to the pathogenesis and therapy of allergic diseases.
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Tamura,H.,Mochizuki,H.,Shigeta,M.,et al.: "Studies of dialyzates from Dermatophagoides farinae:Partial purification and haptenic properties of dialyzates from Df." Int Arch Allergy Immunol. 96. 322-330 (1991)
Tamura,H.,Mochizuki,H.,Shigeta,M.,et al.:“粉尘螨透析液的研究:Df 透析液的部分纯化和半抗原特性。”
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森川昭廣: "ダニアレルゲンの生物学的特性" 小児科診療. 56. 973-978 (1993)
Akihiro Morikawa:“螨过敏原的生物学特征”儿科学 56. 973-978 (1993)。
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Tamura,H.,Mochizuki,H.,Shigeta,M.,Arakawa,H.,et al.: "Studies of dialyzates from Dermatophagoides farinae:Partial purification and haptenic properties of dialyzates from Dermatophagoides farinae" Int Arch Allergy Immunol. 96. 322-330 (1991)
Tamura,H.,Mochizuki,H.,Shigeta,M.,Arakawa,H.,et al.:“粉尘螨透析液的研究:粉尘螨透析液的部分纯化和半抗原特性”Int Arch Allergy Nutrition。
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黒梅恭芳: "ダニ・食物・小児の健康" 日本小児科学会誌. 97. 279-280 (1993)
Yasuyoshi Kurome:“螨虫、食物和儿童健康”日本儿科学会杂志 97. 279-280 (1993)。
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An Epigenetical Approach for Pathogenesis of Minimal Change Nephrotic Syndrome in Children
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批准号:19591238
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2007
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负责人:MORIKAWA Akihiro
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依托单位:
An Approach to Investigate the Pathogenesis of Allergy in Children Using Epigenetic Status Analysis
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批准号:16390295
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2004
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负责人:MORIKAWA Akihiro
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依托单位:
Mechanisms of exacerbation of asthma induced by RS virus infection and it's regulation due to drugs
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批准号:14570723
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:2002
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负责人:MORIKAWA Akihiro
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依托单位:
ANALYSIS OF MECHANISMS OF DECREASED CERAMIDE PRODUCTION IN CORNEUM STRATUM PATIENTS WITH ATOPIC DERMATITIS
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批准号:11470168
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$1.73万
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财政年份:1999
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负责人:MORIKAWA Akihiro
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依托单位:
海外基金